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Meeting international aerobic physical activity guidelines is associated with enhanced cardiovagal baroreflex sensitivity in healthy older adults

  • Myles W. O’Brien
  • Jarrett A. Johns
  • Tristan W. Dorey
  • Ryan J. Frayne
  • Jonathon R. Fowles
  • Said Mekary
  • Derek S. KimmerlyEmail author
Research Article

Abstract

Purpose

Cardiovagal baroreflex sensitivity (cvBRS) reflects the efficiency of modulating heart rate in response to changes in systolic blood pressure. International guidelines recommend that older adults achieve at least 150 min of moderate–vigorous physical activity per week. We tested the hypothesis that older adults who achieve these guidelines will exhibit greater cardiovagal baroreflex sensitivity versus those who do not.

Methods

A cross-sectional comparison of older adults who did (active, 66 ± 5 years, 251 ± 79 min/week; n = 19) and who did not (inactive, 68 ± 7 years, 89 ± 32 min/week; n = 17) meet the activity guidelines. Beat-by-beat R–R intervals (electrocardiography) and systolic blood pressure (finger photoplethysmography) were recorded. Spontaneous cardiovagal baroreflex sensitivity was assessed using the sequence technique from 10 min of resting supine data. Cardiovagal baroreflex function was also measured during early phase II and phase IV of the Valsalva maneuver. Peak oxygen uptake was determined during maximal cycle ergometry. Moderate–vigorous intensity physical activity and time spent sedentary were assessed over 5 days using the PiezoRx and activPAL, respectively.

Results

Groups had similar peak oxygen uptake (active 25 ± 9 vs. inactive 22 ± 6 ml/kg/min; p = 0.218) and sedentary time (active 529 ± 60 vs. inactive 568 ± 88 min/day; p = 0.130). However, the active group had greater (all, p < 0.019) cvBRS at rest (9.1 ± 2.7 vs. 5.0 ± 1.9 ms/mmHg), during phase II (8.2 ± 3.8 vs. 5.4 ± 2.1 ms/mmHg), and during phase IV (9.9 ± 3.8 vs. 5.6 ± 1.6 ms/mmHg). In the pooled sample, moderate–vigorous physical activity was positively correlated (all, p < 0.015) with spontaneous (R = 0.427), phase II (R = 0.447), and phase IV cvBRS (R = 0.629).

Conclusions

Independent of aerobic fitness and sedentary time, meeting activity guidelines was associated with superior cardiovagal baroreflex sensitivity at rest and during the Valsalva maneuver in older adults.

Keywords

Ageing Blood pressure regulation Valsalva maneuver Objectively measured physical activity 

Notes

Acknowledgements

Support provided by: Canadian Foundation for Innovation: Leader’s Opportunity Fund (DSK) (28311), Faculty of Health Professions Research Development (DSK), Nova Scotia Health Research Foundation (NSHRF) (2016-3993) Development/Innovation (DSK and SM) Grants, as well as the Acadia University McCain Foundation Fund (SM). MWO was supported by a Heart & Stroke BrightRed Scholarship, NS Graduate Scholarship and an NSHRF Scotia Scholars Award.

Compliance with ethical standards

Ethical standards

Research ethics board approval was attained from both Dalhousie and Acadia University. Participants provided written, informed consent prior to study enrollment.

Disclosures

JRF received unrestricted funding from Steps Count Inc. and is the National Chair of Exercise is Medicine Canada.

References

  1. 1.
    Seals DR, Walker AE, Pierce GL, Lesniewski LA (2009) Habitual exercise and vascular ageing. J Physiol 587:5541–5549.  https://doi.org/10.1113/jphysiol.2009.178822 CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Physical Activity Guidelines Advisory Committee (2018) 2018 physical activity guidelines advisory committee scientific report. US Department of Health and Human, Washington, DCGoogle Scholar
  3. 3.
    Tremblay MS, Warburton DE, Janssen I et al (2011) New Canadian physical activity guidelines. Appl Physiol Nutr Metab 36:36–46.  https://doi.org/10.1139/H11-009 CrossRefPubMedGoogle Scholar
  4. 4.
    Paterson DH, Warburton DE (2010) Physical activity and functional limitations in older adults: a systematic review related to Canada’s physical activity guidelines. Int J Behav Nutr Phys Act 7:38.  https://doi.org/10.1186/1479-5868-7-38 CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Colley RC, Butler G, Garriguet D et al (2018) Comparison of self-reported and accelerometer-measured physical activity in Canadian adults. Heal Rep 29:3–15Google Scholar
  6. 6.
    Parati G, Di Rienzo M, Mancia G (2000) How to measure baroreflex sensitivity: from the cardiovascular laboratory to daily life. J Hypertens 18:7–19CrossRefGoogle Scholar
  7. 7.
    Laitinen T, Hartikainen J, Vanninen E et al (1998) Age and gender dependency of baroreflex sensitivity in healthy subjects. J Appl Physiol 84:576–583.  https://doi.org/10.1152/jappl.1998.84.2.576 CrossRefPubMedGoogle Scholar
  8. 8.
    Ormezzano O, Cracowski J-L, Quesada J-L et al (2008) EVAluation of the prognostic value of BARoreflex sensitivity in hypertensive patients: the EVABAR study. J Hypertens 26:1373–1378.  https://doi.org/10.1097/HJH.0b013e3283015e5a CrossRefPubMedGoogle Scholar
  9. 9.
    Yang H, Carter JR (2013) Baroreflex sensitivity analysis: spontaneous methodology vs. Valsalva’s maneuver. Clin Auton Res 23:133–139.  https://doi.org/10.1007/s10286-013-0195-9 CrossRefPubMedGoogle Scholar
  10. 10.
    Hunt BE, Farquhar WB, Taylor JA (2001) Does reduced vascular stiffening fully explain preserved cardiovagal baroreflex function in older, physically active men? Circulation 103:2424–2427.  https://doi.org/10.1161/01.cir.103.20.2424 CrossRefPubMedGoogle Scholar
  11. 11.
    Monahan KD, Dinenno FA, Tanaka H et al (2000) Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men. J Physiol 529:263–271.  https://doi.org/10.1111/j.1469-7793.2000.00263.x CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Monahan K, Tanaka H, Dinenno F, Seals D (2001) Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity. Circulation 104:1627–1632.  https://doi.org/10.1161/hc3901.096670 CrossRefPubMedGoogle Scholar
  13. 13.
    Helmerhorst HJ, Brage S, Warren J et al (2012) A systematic review of reliability and objective criterion-related validity of physical activity questionnaires. Int J Behav Nutr Phys Act 9:103.  https://doi.org/10.1186/1479-5868-9-103 CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Forsén L, Loland NW, Vuillemin A et al (2010) Self-administered physical activity questionnaires for the elderly. Sport Med 40:601–623.  https://doi.org/10.2165/11531350-000000000-00000 CrossRefGoogle Scholar
  15. 15.
    Sala R, Malacarne M, Pagani M, Lucini D (2015) Evidence of increased cardiac parasympathetic drive in subjects meeting current physical activity recommendations. Clin Auton Res 25:285–291.  https://doi.org/10.1007/s10286-015-0300-3 CrossRefPubMedGoogle Scholar
  16. 16.
    Sobierajski FM, Purdy GM, Usselman CW et al (2018) Maternal physical activity is associated with improved blood pressure regulation during late pregnancy. Can J Cardiol 34:485–491.  https://doi.org/10.1016/j.cjca.2018.01.021 CrossRefPubMedGoogle Scholar
  17. 17.
    Hart TL, Swartz AM, Cashin SE, Strath SJ (2011) How many days of monitoring predict physical activity and sedentary behaviour in older adults? Int J Behav Nutr Phys Act 8:62.  https://doi.org/10.1186/1479-5868-8-62 CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    O’Brien M, Wojcik W, D’Entremont L, Fowles J (2018) Validation of the PiezoRx® step count and moderate to vigorous physical activity times in free living conditions in adults: a pilot study. Int J Exerc Sci 11:541–551PubMedPubMedCentralGoogle Scholar
  19. 19.
    O’Brien M, Wojcik W, Fowles J (2018) Medical-grade physical activity monitoring for measuring step count and moderate-to-vigorous physical activity: validity and reliability study. JMIR mHealth uHealth 6:e10706.  https://doi.org/10.2196/10706 CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    O’Brien M, Kivell MJ, Wojcik WR et al (2018) Influence of anthropometrics on step-rate thresholds for moderate and vigorous physical activity in older adults: scientific modeling study. JMIR Aging 1:e12363.  https://doi.org/10.2196/12363 CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Serrano F, Slaght J, Sénéchal M et al (2017) Identification and prediction of the walking cadence required to reach moderate intensity using individually-determined relative moderate intensity in older adults. J Aging Phys Act 25:205–211.  https://doi.org/10.1123/japa.2015-0262 CrossRefPubMedGoogle Scholar
  22. 22.
    Tudor-Locke C, Han H, Aguiar E et al (2018) How fast is fast enough? Walking cadence (steps/min) as a practical estimate of intensity in adults: a narrative review. Br J Sport Med 52:776–788.  https://doi.org/10.1136/bjsports-2017-097628 CrossRefGoogle Scholar
  23. 23.
    Edwardson C, Winkler E, Bodicoat D et al (2017) Considerations when using the activPAL monitor in field-based research with adult populations. J Sport Heal Sci 6:162–178.  https://doi.org/10.1016/j.jshs.2016.02.002 CrossRefGoogle Scholar
  24. 24.
    Parlow J, Viale J, Annat G et al (1995) Spontaneous cardiac baroreflex in humans. Comparison with drug-induced responses. Hypertension 25:1058–1068.  https://doi.org/10.1161/01.hyp.25.5.1058 CrossRefPubMedGoogle Scholar
  25. 25.
    Blaber AP, Yamamoto Y, Hughson RL (1995) Methodology of spontaneous baroreflex relationship assessed by surrogate data analysis. Am J Physiol 268:H1682–H1687.  https://doi.org/10.1152/ajpheart.1995.268.4.H1682 CrossRefPubMedGoogle Scholar
  26. 26.
    Teixeira AL, Ritti-Dias R, Antonino D et al (2018) Sex differences in cardiac baroreflex sensitivity after isometric handgrip exercise. Med Sci Sport Exerc 50:770–777.  https://doi.org/10.1249/MSS.0000000000001487 CrossRefGoogle Scholar
  27. 27.
    Chapleau MW, Sabharwal R (2011) Methods of assessing vagus nerve activity and reflexes. Heart Fail Rev 16:109–127.  https://doi.org/10.1007/s10741-010-9174-6 CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Di Rienzo M, Parati G, Castiglioni P et al (2001) Baroreflex effectiveness index: an additional measure of baroreflex control of heart rate in daily life. Am J Physiol Integr Comp Physiol 280:R744–R751.  https://doi.org/10.1152/ajpregu.2001.280.3.R744 CrossRefGoogle Scholar
  29. 29.
    Cooke WH, Reynolds BV, Yandl MG et al (2002) Effects of exercise training on cardiovagal and sympathetic responses to Valsalva’s maneuver. Med Sci Sports Exerc 34:928–935CrossRefGoogle Scholar
  30. 30.
    Smith ML, Beightol LA, Fritsch-Yelle JM et al (1996) Valsalva’s maneuver revisited: a quantitative method yielding insights into human autonomic control. Am J Physiol 271:H1240–H1249.  https://doi.org/10.1152/ajpheart.1996.271.3.H1240 CrossRefPubMedGoogle Scholar
  31. 31.
    Wada N, Singer W, Gehrking TL et al (2014) Determination of vagal baroreflex sensitivity in normal subjects. Muscle Nerve 50:535–540.  https://doi.org/10.1002/mus.24191 CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Hinkle D, Wiersma W, Jurs S (2003) Applied statistics for behavioural sciences, 5th edn. Houghton Mifflin, BostonGoogle Scholar
  33. 33.
    Costa AM, Breitenfeld L, Silva AJ et al (2012) Genetic inheritance effects on endurance and muscle strength. Sport Med 42:449–458.  https://doi.org/10.2165/11650560-000000000-00000 CrossRefGoogle Scholar
  34. 34.
    Madden KM, Lockhart C, Potter TF, Cuff D (2010) Aerobic training restores arterial baroreflex sensitivity in older adults with type 2 diabetes, hypertension, and hypercholesterolemia. Clin J Sport Med 20:312–317.  https://doi.org/10.1097/JSM.0b013e3181ea8454 CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    DeSouza CA, Shapiro LF, Clevenger CM et al (2000) Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 102:1351–1357.  https://doi.org/10.1161/01.cir.102.12.1351 CrossRefPubMedGoogle Scholar
  36. 36.
    Johansson M, Gao S, Friberg P et al (2005) Reduced baroreflex effectiveness index in hypertensive patients with chronic renal failure. Am J Hypertens 18:995–1000.  https://doi.org/10.1016/j.amjhyper.2005.02.002 CrossRefPubMedGoogle Scholar
  37. 37.
    Tank J, Baevski R, Flender A et al (2000) Reference values of indices of spontaneous baroreceptor reflex sensitivity. Am J Hypertens 13:268–275.  https://doi.org/10.1016/s0895-7061(99)00172-7 CrossRefPubMedGoogle Scholar
  38. 38.
    Eckberg DL (1980) Parasympathetic cardiovascular control in human disease: a critical review of methods and results. Am J Physiol Circ Physiol 239:H581–H593.  https://doi.org/10.1152/ajpheart.1980.239.5.H581 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Kinesiology, School of Health and Human Performance, Faculty of HealthDalhousie UniversityHalifaxCanada
  2. 2.Libin Cardiovascular Institute of Alberta, Department of Cardiac Science, Department of Physiology and Pharmacology, Cumming School of MedicineUniversity of CalgaryCalgaryCanada
  3. 3.School of KinesiologyAcadia UniversityWolfvilleCanada

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