Gastrointestinal function in dementia with Lewy bodies: a comparison with Parkinson disease

  • Hirokazu Doi
  • Ryuji SakakibaraEmail author
  • Masayuki Masuda
  • Fuyuki Tateno
  • Yosuke Aiba
  • Masahiko Kishi
  • Tomonori Yamanishi
  • Tatsuya Yamamoto
  • Katsuyoshi Matsuoka
Short Communication



To investigate gastrointestinal function in dementia with Lewy bodies and Parkinson disease.


We examined gastric emptying and colonic transit time in 19 dementia with Lewy bodies and 46 Parkinson disease patients.


Gastric emptying was longer in dementia with Lewy bodies than in Parkinson disease (p = 0.014). Colonic transit time tended to be longer in dementia with Lewy bodies than in Parkinson disease. There was no relationship between gastric emptying and colonic transit time, nor between gastric emptying, colonic transit time and age.


Gastric emptying was prolonged in dementia with Lewy bodies compared to Parkinson disease.


Dementia with Lewy bodies Parkinson disease Gastric emptying Colonic transit time Constipation 


Author contributions

Hirokazu Doi had a role in: acquisition, analysis and interpretation of data. Ryuji Sakakibara had a role in: study concept and design, acquisition of subjects and/or data, analysis and interpretation of data, and preparation of manuscript. Mitsutoshi Sato had a role in: acquisition, analysis and interpretation of data. Masayuki Masuda had a role in: acquisition, analysis and interpretation of data. Fuyuki Tateno had a role in: acquisition, analysis and interpretation of data. Yosuke Aiba had a role in: acquisition, analysis and interpretation of data. Masahiko Kishi had a role in: acquisition of subjects and/or data. Tomonori Yamanishi had a role in: review of data. Tatsuya Yamamoto had a role in: review of data. Katsuyoshi Matsuoka had a role in: acquisition of subjects and/or data.

Compliance with ethical standards

Conflict of interest

None of the authors have any conflicts of interest to declare.


  1. 1.
    McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M; Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65: 1863–1872Google Scholar
  2. 2.
    Goodman RA, Lochner KA, Thambisetty M et al (2017) Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011–2013. Alzheimers Dement. 13:28–37CrossRefPubMedGoogle Scholar
  3. 3.
    Orme T, Guerreiro R, Bras J (2018) The genetics of dementia with Lewy bodies: current understanding and future directions. Curr Neurol Neurosci Rep. 18:67. CrossRefPubMedGoogle Scholar
  4. 4.
    Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184CrossRefPubMedGoogle Scholar
  5. 5.
    Pfeiffer RF (2018) Gastrointestinal dysfunction in Parkinson’s disease. Curr Treat Options Neurol. 20:54. CrossRefPubMedGoogle Scholar
  6. 6.
    Knudsen K, Szwebs M, Hansen AK, Borghammer P (2018) Gastric emptying in Parkinson’s disease: a mini-review. Parkinsonism Relat Disord. 55:18–25CrossRefPubMedGoogle Scholar
  7. 7.
    Sakakibara R, Tateno F, Aiba Y, Ogata T, Kishi M, Terada H, Inaoka T, Nakatsuka T, Matsuoka K. MIBG myocardial scintigraphy identifies premotor PD/DLB during a negative DAT scan period: second report. Mov Disord Clinical Pract 2019: in pressGoogle Scholar
  8. 8.
    Sakakibara R, Odaka T, Uchiyama T, Asahina M, Yamaguchi K, Yamaguchi T, Yamanishi T, Hattori T (2003) Colonic transit time and rectoanal videomanometry in Parkinson’s disease. J Neurol Neurosurg Psychiatry 74:268–272CrossRefPubMedGoogle Scholar
  9. 9.
    Doi H, Sakakibara R, Sato M, Masaka T, Kishi M, Tateno A, Tateno F, Tsuyusaki Y, Takahashi O (2012) Plasma levodopa peak delay and impaired gastric emptying in Parkinson’s disease. J Neurol Sci 319:86–88CrossRefPubMedGoogle Scholar
  10. 10.
    Folstein M, Folstein S, McHugh PR (1975) Mini-mental state; a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198CrossRefPubMedGoogle Scholar
  11. 11.
    Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ, Vantrappen G (1993) Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 104:1640–1647CrossRefPubMedGoogle Scholar
  12. 12.
    Nakada K, Aoyama N, Nakagawa M, Kawasaki N, Shirasaka D, Zai H, Urita Y, Kitagawa Y, Koyama S, Shishido T, Kusunoki H, Kato M, Hanyu N, Haruma K, Hongo M (2002) The report of the workshop entitled “The present and the future in gastric emptying study assessed by 13C breath test: with special reference to the standardization of the method” at the 44th Annual Meeting of the Japanese Smooth Muscle Society. J Smooth Muscle Res 6:75–91CrossRefGoogle Scholar
  13. 13.
    Devroede G (1993) Radiopaque marker measurement of colorectal transit. In: Schuster MM (ed) Atlas of gastrointestinal motility in health and disease, Chapter 3. Williams and Wilkins, Baltimore, pp 57–75Google Scholar
  14. 14.
    Sakakibara R, Doi H, Fukudo S. Lewy body constipation. J Anus Rectum, 2018: in pressGoogle Scholar
  15. 15.
    Shannon K, Vanden Berghe P (2018) The enteric nervous system in PD: gateway, bystander victim, or source of solutions. Cell Tissue Res 373:313–326CrossRefPubMedGoogle Scholar
  16. 16.
    Abbott RD, Petrovitch H, White LR, Masaki KH, Tanner CM, Curb JD et al (2001) Frequency of bowel movements and the future risk of Parkinson’s disease. Neurology 57:456–462CrossRefPubMedGoogle Scholar
  17. 17.
    Giancola F, Torresan F, Repossi R, Bianco F, Latorre R, Ioannou A, De Giorgio R (2016) Downregulation of neuronal vasoactive intestinal polypeptide in Parkinson’s disease and chronic constipation. Neurogastroenterol Motility 29:e12995. CrossRefGoogle Scholar
  18. 18.
    Svensson E, Horváth-Puhó E, Thomsen RW, Djurhuus JC, Pedersen L, Borghammer P, Sørensen HT (2015) Vagotomy and subsequent risk of Parkinson’s disease. Ann Neurol 78:522–529CrossRefPubMedGoogle Scholar
  19. 19.
    Kujawska M, Jodynis-Liebert J (2018) What is the evidence that Parkinson’s disease is a prion disorder, which originates in the gut? Int J Mol Sci. 19(11):22. CrossRefGoogle Scholar
  20. 20.
    Lee HJ, Jung KW, Chung SJ, Hong SM, Kim J, Lee JH, Hwang SW, Ryu HS, Kim MJ, Lee HS, Seo M, Park SH, Yang DH, Ye BD, Byeon JS, Choe J, Jung HY, Yang SK, Myung SJ. Relation of enteric α-synuclein to gastrointestinal dysfunction in patients with Parkinson’s disease and in neurologically intact subjects. J Neurogastroenterol Motil. 2018; 24:469–478Google Scholar
  21. 21.
    Liddle RA (2018) Parkinson’s disease from the gut. Brain Res 1693(Pt B):201–206CrossRefPubMedGoogle Scholar
  22. 22.
    Anselmi L, Toti L, Bove C, Hampton J, Travagli RA (2017) A nigrolvagal pathway controls gastric motility and is affected in a rat model of parkinsonism. Gastroenterology 153:1581–1593CrossRefPubMedGoogle Scholar
  23. 23.
    Sakakibara Y, Asahina M, Suzuki A, Hattori T (2009) Gastric myoelectrical differences between Parkinson’s disease and multiple system atrophy. Mov Disord 24:1579–1586CrossRefPubMedGoogle Scholar
  24. 24.
    Goetze O, Nikodem AB, Wiezcorek J, Banasch M, Przuntek H, Mueller T, Schmidt WE, Woitalla D (2006) Predictors of gastric emptying in Parkinson’s disease. Neurogastroenterol Motil 18:369–375CrossRefPubMedGoogle Scholar
  25. 25.
    Merchant HA, Liu F, Orlu Gul M, Basit AW (2016) Age-mediated changes in the gastrointestinal tract. Int J Pharm 512:382–395CrossRefPubMedGoogle Scholar
  26. 26.
    Fich A, Camilleri M, Phillips SF (1989) Effect of age on human gastric and small bowel motility. J Clin Gastroenterol 11:416–420CrossRefPubMedGoogle Scholar
  27. 27.
    Tateno F, Sakakibara R, Kishi M, Ogawa E, Yoshimatsu Y, Takada N, Suzuki Y, Mouri T, Uchiyama T, Yamamoto T (2011) Incidence of emergency intestinal pseudo-obstruction in Parkinson’s disease. J Am Geriatr Soc 59:2373–2375CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Pharmaceutical Unit, Sakura Medical CenterToho UniversitySakuraJapan
  2. 2.Neurology, Internal Medicine, Sakura Medical CenterToho UniversitySakuraJapan
  3. 3.Continence CenterDokkyo Medical CollegeTochigiJapan
  4. 4.Neurology Chiba University, Toho UniversitySakuraJapan
  5. 5.Gastroenterology, Internal Medicine, Sakura Medical CenterToho UniversitySakuraJapan

Personalised recommendations