Skip to main content

Advertisement

SpringerLink
Log in

The association between symptoms of sexual dysfunction and age at onset in Parkinson’s disease

  • Research Article
  • Published:
Clinical Autonomic Research Aims and scope Submit manuscript

Abstract

Objective

Age at onset in Parkinson’s disease (PD) seems to be related nonmotor symptoms. In this study we investigated the effect of the age at onset on symptoms of sexual dysfunction (SSD) in patients with PD.

Methods

This prospective study comprised 22 consecutive outpatients with early onset PD (EOPD—onset of the disease before 55 years), and 66 outpatients with late onset PD (LOPD—onset of PD over 55 years). They were all recruited from the Department of Movement Disorders, Clinic of Neurology. The diagnosis was established according to the UK PD Brain Bank Criteria by a movement disorders specialist. The Unified PD Rating Scale (UPDRS) motor was used to assess motor disability and Hoehn and Yahr (H&Y) stage was used to establish disease severity. The sexual functions of the patients were rated by applying the Arizona Sexual Experiences Scale (ASEX).

Results

Thirteen EOPD patients (59.09 %) and 53 of the LOPD patients (80.3 %) (p 0.047) reported dissatisfaction with at least one item of ASEX. There were no differences between H&Y stages (p 0.205) UPDRS total (p 0.267) and motor scores (p 0.100) between groups. LOPD patients had significantly higher ASEX scores than EOPD patients (p 0.001).

Interpretation

Sexual dysfunciton occurs more frequently and more severely in LOPD than EOPD patients. PD patients with different ages at onset clinically present differently in terms of SSD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Lim SY, Lang AE (2010) The nonmotor symptoms of Parkinson’s disease—an overview. Mov Disord 25:123–130

    Article  Google Scholar 

  2. Murakami T, Shoji M, Imai Y et al (2004) Pael-R is accumulated in Lewy bodies of Parkinson’s disease. Ann Neurol 55:439

    Article  CAS  PubMed  Google Scholar 

  3. Wakabayashi K, Tanji K, Mori F, Takahashi H (2007) The Lewy body in Parkinson’s disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates. Neuropathology 27:494

    Article  PubMed  Google Scholar 

  4. Barone P, Antonini A, Colosimo C et al (2009) The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 2411:1641–1649

    Article  Google Scholar 

  5. Goetz CG, Tilley BC, Shaftman SR et al (2008) Movement disorder society-sponsored revision of the unified parkinson’s disease rating scale [MDS-UPDRS]: scale presentation and clinimetric testing results. Mov Disord 2315:2129–2170

    Article  Google Scholar 

  6. Martinez-Martin P, Falup Pecurariu C, Odin P et al (2012) Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease. J Neurol 2598:1639–1647

    Article  Google Scholar 

  7. Bronner G, Royter V, Korczyn AD, GIladI N (2004) Sexual dysfunction in Parkinson’s disease. J Sex Marital Ther 30:95–105

    Article  PubMed  Google Scholar 

  8. Meco G, Rubino A, Caravona N, Valente M (2008) Sexual dysfunction in Parkinson’s disease. Parkinsonism Relat Disord 14:451–456

    Article  PubMed  Google Scholar 

  9. Quinn N, Critchley P, Marsden CD (1987) Young-onset Parkinson’s disease. Mov Disord 2:73–91

    Article  CAS  PubMed  Google Scholar 

  10. Schrag A, Schott JM (2006) Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism. Lancet Neurol 54:355–363

    Article  Google Scholar 

  11. Schrag A, Hovris A, Morley D, Quinn N, Jahanshahi M (2003) Young- versus older onset Parkinson’s disease: impact of disease and psychosocial consequences. Mov Disord 1811:1250–1256

    Article  Google Scholar 

  12. Wıckremaratchi MM, Ben-Shiomo Y, Morris HR (2009) The effect of onset age on the clinical features of Parkinson’s disease. Eur J Neurol 6:450–456

    Article  Google Scholar 

  13. Jacobs H, Vieregge A, Vieregge P (2000) Sexuality in young patients with Parkinson’s disease: a population based comparison with healthy controls. J Neurol Neurosurg Psychiatry 69:550–552

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Kummer A, Cardoso F, Teixeira AL (2009) Loss of libido in Parkinson’s disease. J Sex Med 6:1024–1031

    Article  PubMed  Google Scholar 

  15. Guo X, Song W, Chen K et al (2013) Gender and onset age-related features of non-motor symptoms of patients with Parkinson’s disease—a study from Southwest China. Parkinsonism Relat Disord 19:961–996

    Article  PubMed  Google Scholar 

  16. Kempster PA, O’Sullivan SS, Holton JL, Revesz T, Lees AJ (2010) Relationships between age and late progression of Parkinson’s disease: a clinico-pathological study. Brain 133:1755–1762

    Article  PubMed  Google Scholar 

  17. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Hoehn M, Yahr M (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442

    Article  CAS  PubMed  Google Scholar 

  19. Folstein MF, Folstein SE, McHugh PR (1975) ‘‘Mini-mental state’’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198

    Article  CAS  PubMed  Google Scholar 

  20. Güngen C, Ertan T, Eker E, Yaşar R, Engin F (2002) Standardize mini mental test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi 13:273–281

    PubMed  Google Scholar 

  21. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Akdemir A, Örsel S, Dağ İ et al (1996) Hamilton depresyon derecelendirme ölçeği [HDDÖ]’nin geçerliliği, güvenilirliği ve klinikte kullanımı. Psikiyatri Psikoloji Psikofarmakoloji Dergisi 4:251–259

    Google Scholar 

  23. Hamilton M (1959) The assessment of anxiety states by rating. Br J Med Psychol 32:50–55

    Article  CAS  PubMed  Google Scholar 

  24. Yazıcı MK, Demir B, Tanrıverdi N et al (1998) Hamilton Anksiyete Değerlendirme Ölçeği, değerlendiriciler arası güvenirlik ve geçerlilik çalışması. Turk Psikiyatri Derg 9:114–117

    Google Scholar 

  25. McGahuey CA, Gelenberg AJ, Laukes CA, Moreno FA, Delgado PL (2000) The Arizona sexual experience scale [ASEX]: reliability and validity. J Sex Marital Ther 26:25–40

    Article  CAS  PubMed  Google Scholar 

  26. Soykan A (2004) The reliability and validity of Arizona sexual experiences scale in Turkish ESRD patients undergoing hemodialysis. Int J Impot Res 16:531–534

    Article  CAS  PubMed  Google Scholar 

  27. Spica V, Pekmezovic T, Svetel M, Kostic VS (2013) Prevalence of non-motor symptoms in young-onset versus late-onset Parkinson’s disease. J Neurol 2601:131–137

    Article  Google Scholar 

  28. Moore O, Gurevich T, Korczyn AD, Anca M, Shabtai H, Giladi N (2002) Quality of sexual life in Parkinson’s disease. Parkinsonism Relat Disord 8:243–246

    Article  CAS  PubMed  Google Scholar 

  29. Diamond SG, Markham CH, Hoehn MM, McDowell FH, Muenter MD (1989) Effect of age at onset on progression and mortality in Parkinson’s disease. Neurology 39:1187–1190

    Article  CAS  PubMed  Google Scholar 

  30. Kagi G, Klein C, Wood NW et al (2010) Nonmotor symptoms in Parkin gene-related parkinsonism. Mov Disord 259:1279–1284

    Article  Google Scholar 

  31. Dickson DW, Fujishiro H, Orr C et al (2009) Neuropathology of non-motor features of Parkinson disease. Parkinsonism Relat Disord 15:S1–S5

    Article  PubMed  Google Scholar 

  32. Chaudhuri KR, Schapira AH (2009) Non-motor symptoms of Parkinson’s disease: dopaminergic pathophysiology and treatment. Lancet Neurol 8:464–474

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, School of Medicine, Ordu University, Ordu, Turkey

    Tuba Özcan

  2. Department of Urology, School of Medicine, Ordu University, Ordu, Turkey

    Erdal Benli & Ali Ayyıldız

  3. Department of Neurology, School of Medicine, Medipol University, İstanbul, Turkey

    Feriha Özer

  4. Department of Psychiatry, School of Medicine, Ordu University, Ordu, Turkey

    Esra Yancar Demir

  5. Department of Internal Medicine, School of Medicine, Ordu University, Ordu, Turkey

    Yasemin Kaya

Authors
  1. Tuba Özcan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Erdal Benli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Feriha Özer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Esra Yancar Demir
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yasemin Kaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ali Ayyıldız
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tuba Özcan.

Ethics declarations

Financial support

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Conflicts of interest

The authors report no conflict of interest.

Ethical standards

The authors assert that all procedures are contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Özcan, T., Benli, E., Özer, F. et al. The association between symptoms of sexual dysfunction and age at onset in Parkinson’s disease. Clin Auton Res 26, 205–209 (2016). https://doi.org/10.1007/s10286-016-0356-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10286-016-0356-8

Keywords

Search

Navigation