Clinical Autonomic Research

, Volume 25, Issue 4, pp 267–270 | Cite as

Acute inhalation of vaporized nicotine increases arterial pressure in young non-smokers: a pilot study

  • William H. CookeEmail author
  • Anusheela Pokhrel
  • Colin Dowling
  • Donovan L. Fogt
  • Caroline A. Rickards
Short Communication



Electronic cigarettes are growing in popularity, but the physiological consequences of vaporized nicotine are unknown.


Twenty healthy non-smokers inhaled vaporized nicotine and placebo (randomized).


Nicotine inhalation was associated with higher arterial pressures in the seated position, and increased arterial pressures in the head-up positions with no other effects on autonomic control.


Our results show that vaporized nicotine inhalation is not innocuous. Longitudinal studies in otherwise healthy non-smokers should be conducted.


Electronic cigarettes Head-up tilt Blood pressure Autonomic control 



This study was supported by a Collaborative Seed Grant through the Office of the Vice President for Research, University of Texas at San Antonio, San Antonio Texas. We appreciate the technical assistance of Ms. Audrey Ramirez.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • William H. Cooke
    • 1
    Email author
  • Anusheela Pokhrel
    • 1
  • Colin Dowling
    • 1
  • Donovan L. Fogt
    • 1
  • Caroline A. Rickards
    • 2
  1. 1.Department of Kinesiology, Health, and NutritionThe University of Texas at San AntonioSan AntonioUSA
  2. 2.Department of Integrative Physiology and AnatomyThe University of North Texas Health Science CenterFort WorthUSA

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