Clinical Autonomic Research

, Volume 22, Issue 6, pp 303–306 | Cite as

Temporary elimination of orthostatic hypotension by norepinephrine infusion

  • David S. Goldstein
  • LaToya Sewell
  • Courtney Holmes
  • Sandra Pechnik
  • André Diedrich
  • David Robertson
Short Communication


A cardinal manifestation of chronic autonomic failure is neurogenic orthostatic hypotension (OH), which often is associated with supine hypertension, posing a therapeutic dilemma. We report here success in a first step toward development of a “prosthetic baroreceptor system” to maintain blood pressure during orthostasis without worsening supine hypertension. In all of four patients with neurogenic OH, titrated i.v. NE infusion kept directly recorded intra-arterial pressure at or above baseline during progressive head-up tilt. We conclude that titrated i.v. NE infusion temporarily eliminates OH.


Norepinephrine Orthostatic hypotension Sympathetic nervous system Baroreflex 





Orthostatic hypotension



The research reported here was supported by the Division of Intramural Research of the National Institute of Neurological Disorders and Stroke.

Conflict of interest

The authors have no conflicts of interest to disclose.


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Copyright information

© Springer-Verlag (outside the USA)  2012

Authors and Affiliations

  • David S. Goldstein
    • 1
  • LaToya Sewell
    • 1
  • Courtney Holmes
    • 1
  • Sandra Pechnik
    • 1
  • André Diedrich
    • 2
  • David Robertson
    • 3
  1. 1.Clinical Neurocardiology SectionNational Institute of Neurological Disorders and Stroke, National Institutes of HealthBethesdaUSA
  2. 2.Department of Biomedical EngineeringVanderbilt UniversityNashvilleUSA
  3. 3.Autonomic Dysfunction CenterVanderbilt University School of MedicineNashvilleUSA

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