Fludrocortisone improves nausea in children with orthostatic intolerance (OI)
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In 17 patients, chronic idiopathic nausea was associated with orthostatic intolerance (OI) by abnormal tilt table tests (88%) or gastric dysrhythmias (71%). After fludrocortisone treatment, there was >26% nausea improvement in 71%, 1–25% in 6%, and no improvement in 24%. In six subjects, EGGs repeated after >50% nausea improvement all remained to be abnormal, suggesting nausea is independent of gastric dysrhythmias.
Association of EGG abnormalities and OI in this subset of nausea patients suggests a generalized disturbance of autonomic regulation.
KeywordsFludrocortisone acetate chronic idiopathic nausea Orthostatic intolerance (OI) Postural orthostatic tachycardia syndrome (POTS) Neurally mediated hypotension (NMH) Electrogastrography Tilt table testing
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