Clinical Autonomic Research

, Volume 19, Issue 3, pp 137–148 | Cite as

Cardiac sympathetic neuroimaging: summary of the First International Symposium

Review Article


The First International Symposium on Cardiac Sympathetic Neuroimaging brought together for the first time clinical and preclinical researchers evaluating autonomic and neurocardiologic disorders by this modality. The invited lectures and posters presented some uses of cardiac sympathetic neuroimaging for diagnosis, prognosis, and monitoring treatments. The Symposium also included a discussion about whether and how to expand the availability of cardiac sympathetic neuroimaging at medical centers in the United States. Here, we review the background for the Symposium, provide an annotated summary of the lectures and posters, discuss some of the take-home points from the roundtable discussion, and propose a plan of action for the future.


Sympathetic nervous system Fluorodopamine MIBG Positron-emission tomography 


  1. 1.
    Akashi YJ, Goldstein DS, Barbaro G, Ueyama T Takotsubo cardiomyopathy: a new form of acute, reversible heart failure. Circulation (in press)Google Scholar
  2. 2.
    Dickson DW, Fujishiro H, DelleDonne A, Menke J, Ahmed Z, Klos KJ, Josephs KA, Frigerio R, Burnett M, Parisi JE, Ahlskog JE (2008) Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease. Acta Neuropathologica 115:437–444PubMedCrossRefGoogle Scholar
  3. 3.
    Goldstein DS, Holmes C, Bentho O, T. S, Moak J, Sharabi Y, Imrich R, Conant T, Eldadah BA Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy. Parkinsonism Relat Disord (in press)Google Scholar
  4. 4.
    Goldstein DS, Holmes C, Sato T, Bernson M, Mizrahi N, Imrich R, Carmona G, Sharabi Y, Vortmeyer AO (2008) Central dopamine deficiency in pure autonomic failure. Clin Auton Res (in press)Google Scholar
  5. 5.
    Goldstein DS, Sharabi Y, Karp BI, Bentho O, Saleem A, Pacak K, Eisenhofer G (2007) Cardiac sympathetic denervation preceding motor signs in Parkinson disease. Clin Auton Res 17:118–121PubMedCrossRefGoogle Scholar
  6. 6.
    Kasama S, Toyama T, Kumakura H, Takayama Y, Ichikawa S, Suzuki T, Kurabayashi M (2005) Effects of candesartan on cardiac sympathetic nerve activity in patients with congestive heart failure and preserved left ventricular ejection fraction. J Am Coll Cardiol 45:661–667PubMedCrossRefGoogle Scholar
  7. 7.
    Kasama S, Toyama T, Sumino H, Nakazawa M, Matsumoto N, Sato Y, Kumakura H, Takayama Y, Ichikawa S, Suzuki T, Kurabayashi M (2008) Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction. J Nucl Med 49:907–914PubMedCrossRefGoogle Scholar
  8. 8.
    Kioka H, Yamada T, Mine T, Morita T, Tsukamoto Y, Tamaki S, Masuda M, Okuda K, Hori M, Fukunami M (2007) Prediction of sudden death in patients with mild-to-moderate chronic heart failure by using cardiac iodine-123 metaiodobenzylguanidine imaging. Heart 93:1213–1218PubMedCrossRefGoogle Scholar
  9. 9.
    Kollensperger M, Seppi K, Liener C, Boesch S, Heute D, Mair KJ, Mueller J, Sawires M, Scherfler C, Schocke MF, Donnemilier E, Virgolini I, Wenning GK, Poewe W (2007) Diffusion weighted imaging best discriminates PD from MSA-P: a comparison with tilt table testing and heart MIBG scintigraphy. Mov DisordGoogle Scholar
  10. 10.
    Kvetnansky R, Goldstein DS, Weise VK, Holmes C, Szemeredi K, Bagdy G, Kopin IJ (1992) Effects of handling or immobilization on plasma levels of 3, 4-dihydroxyphenylalanine, catecholamines, and metabolites in rats. J Neurochem 58:2296–2302PubMedCrossRefGoogle Scholar
  11. 11.
    Lee PH, Yeo SH, Kim HJ, Youm HY (2006) Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson’s disease and multiple system atrophy. Mov Disord 21:1975–1977PubMedCrossRefGoogle Scholar
  12. 12.
    Matsui T, Tsutamoto T, Maeda K, Kusukawa J, Kinoshita M (2002) Prognostic value of repeated 123I-metaiodobenzylguanidine imaging in patients with dilated cardiomyopathy with congestive heart failure before and after optimized treatments—comparison with neurohumoral factors. Circ J 66:537–543PubMedCrossRefGoogle Scholar
  13. 13.
    Orimo S, Amino T, Itoh Y, Takahashi A, Kojo T, Uchihara T, Tsuchiya K, Mori F, Wakabayashi K, Takahashi H (2005) Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. Acta Neuropathol (Berl) 109:583–588CrossRefGoogle Scholar
  14. 14.
    Orimo S, Kanazawa T, Nakamura A, Uchihara T, Mori F, Kakita A, Wakabayashi K, Takahashi H (2007) Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. Acta Neuropathol (Berl) 113:81–86CrossRefGoogle Scholar
  15. 15.
    Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, Takahashi H (2008) Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson’s disease. Brain 131:642–650PubMedCrossRefGoogle Scholar
  16. 16.
    Senard JM, Brefel-Courbon C, Rascol O, Montastruc JL (2001) Orthostatic hypotension in patients with Parkinson’s disease: pathophysiology and management. Drugs Aging 18:495–505PubMedCrossRefGoogle Scholar
  17. 17.
    Sharabi Y, Imrich R, Holmes C, Pechnik S, Goldstein DS ((in press)) Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson disease with orthostatic hypotension. Mov DisordGoogle Scholar
  18. 18.
    Ueyama T, Hano T, Kasamatsu K, Yamamoto K, Tsuruo Y, Nishio I (2003) Estrogen attenuates the emotional stress-induced cardiac responses in the animal model of Tako-tsubo (Ampulla) cardiomyopathy. J Cardiovasc Pharmacol 42(Suppl 1):S117–S119PubMedGoogle Scholar
  19. 19.
    Ueyama T, Tanioku T, Nuta J, Kujira K, Ito T, Nakai S, Tsuruo Y (2006) Estrogen alters c-Fos response to immobilization stress in the brain of ovariectomized rats. Brain Res 1084:67–79PubMedCrossRefGoogle Scholar
  20. 20.
    Valli N, Labrousse L, Reant P, Dos-Santos P (2007) Significant improvement of cardiac sympathetic function following cardiac support device implantation: illustration by 123I-MIBG scintigraphy. Eur J Cardiothorac Surg 32:943–944PubMedCrossRefGoogle Scholar
  21. 21.
    Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC (2005) Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352:539–548PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Clinical Neurosciences Program, Clinical Neurocardiology Section, Division of Intramural Research, National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaUSA
  2. 2.Kanto Central HospitalTokyoJapan

Personalised recommendations