Clinical Autonomic Research

, 18:325 | Cite as

Firing properties of sudomotor neurones in hyperhidrosis and thermal sweating

  • Vaughan G. Macefield
  • Yrsa B. Sverrisdottir
  • Mikael Elam
  • John Harris
RESEARCH ARTICLE

Abstract

Objectives

Idiopathic palmar-plantar hyperhidrosis is characterized by excessive sweating of the palms and feet, and is commonly treated by transthoracic regional sympathicotomy. As the condition is believed to be due to a high sudomotor drive, we wanted to assess the firing properties of individual sudomotor neurones in this state of sympathoexcitation, extending our recent work on other pathologies associated with high sympathetic nerve activity.

Methods

Single-unit recordings were made from eight sudomotor neurones supplying the fingers via tungsten microelectrodes inserted percutaneously into the median nerve at the wrist or upper arm.

Results

Typical of sudomotor, muscle vasoconstrictor and cutaneous vasoconstrictor neurones recorded in healthy individuals in states of high sympathetic drive, all units had low firing probabilities (active in only 30.0 ± 6.7 (SE) % of cardiac intervals) and primarily fired only once per heart beat. The percentage of cardiac intervals in which the neurones generated 1, 2, 3 or 4 spikes was 60.4 ± 6.3, 22.9 ± 3.9, 9.7 ± 2.1 and 3.4 ± 1.3%, respectively. For comparison, these values were 77.6 ± 7.7, 15.0 ± 4.1, 4.6 ± 2.3 and 1.8 ± 1.3% for eight sudomotor neurones innervating the hairy skin of the foot during thermally-induced sweating in normal subjects.

Interpretation

We conclude that the firing properties of spontaneously active sudomotor neurones in subjects with hyperhidrosis are similar to those of sudomotor neurones active during thermal sweating, reflecting an increase in central sympathetic drive to the sweat glands in hyperhidrosis.

Keywords

microneurography single-unit sudomotor sympathetic 

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Copyright information

© Springer 2008

Authors and Affiliations

  • Vaughan G. Macefield
    • 1
    • 2
  • Yrsa B. Sverrisdottir
    • 3
  • Mikael Elam
    • 3
  • John Harris
    • 4
  1. 1.Prince of Wales Medical Research InstituteSydneyAustralia
  2. 2.School of MedicineUniversity of Western SydneyPenrith South DCAustralia
  3. 3.Institute for Clinical NeuroscienceSahlgren University HospitalGöteborgSweden
  4. 4.Dept. of Vascular SurgeryRoyal Prince Alfred HospitalSydneyAustralia

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