Pyridostigmine in autonomic failure: can we treat postural hypotension and bladder dysfunction with one drug?
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In a 66-year-old man with autonomic failure, pyridostigmine (180 mg/day orally) improved both postural hypotension and underactive detrusor bladder dysfunction. Acetylcholinesterase inhibition may be useful in the management of orthostatic hypotension and bladder dysfunction in autonomic failure patients.
Keywordspyridostigmine pure autonomic failure multiple system atrophy postural hypotension neurogenic underactive bladder
Pure autonomic failure
Multiple system atrophy
Large post-void residuals
Coefficient of variance in electrocardiographic R–R intervals
Clean intermittent catheterization
Continuous positive airway pressure
Apnea hypopnea index
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