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Clinical Autonomic Research

, Volume 16, Issue 4, pp 296–298 | Cite as

Pyridostigmine in autonomic failure: can we treat postural hypotension and bladder dysfunction with one drug?

  • Tatsuya YamamotoEmail author
  • Ryuji Sakakibara
  • Yoshitaka Yamanaka
  • Tomoyuki Uchiyama
  • Masato Asahina
  • Zhi Liu
  • Takashi Ito
  • Yu Koyama
  • Yusuke Awa
  • Kaori Yamamoto
  • Mika Kinou
  • Takamichi Hattori
CASE REPORT

Abstract

In a 66-year-old man with autonomic failure, pyridostigmine (180 mg/day orally) improved both postural hypotension and underactive detrusor bladder dysfunction. Acetylcholinesterase inhibition may be useful in the management of orthostatic hypotension and bladder dysfunction in autonomic failure patients.

Keywords

pyridostigmine pure autonomic failure multiple system atrophy postural hypotension neurogenic underactive bladder 

Abbreviations

PAF:

Pure autonomic failure

MSA:

Multiple system atrophy

PVR:

Large post-void residuals

CvRR:

Coefficient of variance in electrocardiographic R–R intervals

CIC:

Clean intermittent catheterization

CPAP:

Continuous positive airway pressure

AHI:

Apnea hypopnea index

l-threo DOPS:

l-threo-dihydroxyphenylserine

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Copyright information

© Steinkopff Verlag Darmstadt 2006

Authors and Affiliations

  • Tatsuya Yamamoto
    • 1
    Email author
  • Ryuji Sakakibara
    • 1
  • Yoshitaka Yamanaka
    • 1
  • Tomoyuki Uchiyama
    • 1
  • Masato Asahina
    • 1
  • Zhi Liu
    • 1
  • Takashi Ito
    • 1
  • Yu Koyama
    • 1
  • Yusuke Awa
    • 2
  • Kaori Yamamoto
    • 2
  • Mika Kinou
    • 2
  • Takamichi Hattori
    • 1
  1. 1.Dept. of NeurologyChiba UniversityChibaJapan
  2. 2.Dept. of UrologyChiba UniversityChibaJapan

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