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Clinical Autonomic Research

, Volume 13, Issue 2, pp 96–98 | Cite as

Primary hyperhidrosis

Evidence for autosomal dominant inheritance
  • Horacio Kaufmann
  • Daniela Saadia
  • Charlene Polin
  • Stephen Hague
  • Amanda Singleton
  • Andrew Singleton
RESEARCH ARTICLE

Abstract.

Primary hyperhidrosis is a neurogenic disorder of unknown cause characterized by excessive sweating in the palmar surface of the hands, armpits, groin and feet. In the course of a therapeutic trial for primary hyperhidrosis, 62 % of patients reported a positive family history. Examination of these pedigrees demonstrated a sibling recurrence risk of λs = 29–48 and an offspring recurrence risk of λo = 41–68 indicating that hyperhidrosis can be an inherited condition. The pattern of inheritance suggests an autosomal dominant mode of transmission with incomplete disease penetrance.

Key words: hyperhidrosis genetic inheritance autosomal dominant 

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Copyright information

© Steinkopff Verlag 2003

Authors and Affiliations

  • Horacio Kaufmann
    • 1
  • Daniela Saadia
    • 1
  • Charlene Polin
    • 2
  • Stephen Hague
    • 3
  • Amanda Singleton
    • 3
  • Andrew Singleton
    • 3
  1. 1.Dept. of Neurology, Mount Sinai School of Medicine, New York, USAUS
  2. 2.Dept. of Genetics, Mount Sinai School of Medicine, New York, USAUS
  3. 3.Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, Bethesda, USAUS

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