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Clinical Autonomic Research

, Volume 13, Issue 2, pp 106–108 | Cite as

The effect of intranasal desmopressin on nocturnal waking in urination in multiple system atrophy patients with nocturnal polyuria

  • Ryuji Sakakibara
  • Shinji Matsuda
  • Tomoyuki Uchiyama
  • Mitsuharu Yoshiyama
  • Tomonori Yamanishi
  • Takamichi Hattori
RESEARCH LETTER

Abstract.

Nocturnal waking in urination (nocturia) is a common feature in patients with multiple system atrophy (MSA). Degeneration of arginine vasopressin (AVP) neurons in the suprachiasmatic nucleus in this disorder may lead to nocturnal polyuria, which has been treated with intramuscular desmopressin. We also prescribed 5 μg of intranasal desmopressin once a night in 3 MSA patients, who had nocturnal polyuria with abnormal circadian rhythm of the plasma AVP. During the treatment, all patients showed an improvement in their nocturia without serious adverse effects.

Key words: multiple system atrophy (MSA) circadian rhythm arginine vasopressin intranasal desmopressin nocturnal polyuria 

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Copyright information

© Steinkopff Verlag 2003

Authors and Affiliations

  • Ryuji Sakakibara
    • 1
  • Shinji Matsuda
    • 1
  • Tomoyuki Uchiyama
    • 1
  • Mitsuharu Yoshiyama
    • 1
  • Tomonori Yamanishi
    • 2
  • Takamichi Hattori
    • 1
  1. 1.Neurology Department, Chiba University, 1-8-1 Inohana Chuo-Ku, Chiba 260-8670, Japan. sakaki@med.m.chiba-u.ac.jpJP
  2. 2.Department of Urology, Dokkyo Medical College, JapanJP

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