Journal of Digital Imaging

, Volume 27, Issue 1, pp 145–151

A Vector Machine Formulation with Application to the Computer-Aided Diagnosis of Breast Cancer from DCE-MRI Screening Examinations

  • Jacob E. D. Levman
  • Ellen Warner
  • Petrina Causer
  • Anne L. Martel
Article

Abstract

This study investigates the use of a proposed vector machine formulation with application to dynamic contrast-enhanced magnetic resonance imaging examinations in the context of the computer-aided diagnosis of breast cancer. This paper describes a method for generating feature measurements that characterize a lesion’s vascular heterogeneity as well as a supervised learning formulation that represents an improvement over the conventional support vector machine in this application. Spatially varying signal-intensity measures were extracted from the examinations using principal components analysis and the machine learning technique known as the support vector machine (SVM) was used to classify the results. An alternative vector machine formulation was found to improve on the results produced by the established SVM in randomized bootstrap validation trials, yielding a receiver-operating characteristic curve area of 0.82 which represents a statistically significant improvement over the SVM technique in this application.

Keywords

Breast Cancer Detection Computer-Aided Diagnosis Machine Learning Support Vector Machine Receiver-Operating Characteristic Curve Analysis Magnetic Resonance Imaging 

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Copyright information

© Society for Imaging Informatics in Medicine 2013

Authors and Affiliations

  • Jacob E. D. Levman
    • 1
  • Ellen Warner
    • 2
  • Petrina Causer
    • 3
  • Anne L. Martel
    • 4
  1. 1.Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research BuildingUniversity of OxfordOxfordUK
  2. 2.Division of Medical Oncology, Department of MedicineSunnybrook Health Sciences CentreTorontoCanada
  3. 3.Medical Imaging DepartmentNorth York General HospitalTorontoCanada
  4. 4.Department of Medical Biophysics, Sunnybrook Health Sciences CentreUniversity of TorontoTorontoCanada

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