Journal of Digital Imaging

, Volume 21, Issue 4, pp 433–445 | Cite as

Computerized Analysis of Digital Subtraction Angiography: A Tool for Quantitative In-vivo Vascular Imaging

  • George C. Kagadis
  • Panagiota Spyridonos
  • Dimitris Karnabatidis
  • Athanassios Diamantopoulos
  • Emmanouil Athanasiadis
  • Antonis Daskalakis
  • Konstantinos Katsanos
  • Dionisios Cavouras
  • Dimitris Mihailidis
  • Dimitris Siablis
  • George C. Nikiforidis


The purpose of our study was to develop a user-independent computerized tool for the automated segmentation and quantitative assessment of in vivo-acquired digital subtraction angiography (DSA) images. Vessel enhancement was accomplished based on the concept of image structural tensor. The developed software was tested on a series of DSA images acquired from one animal and two human angiogenesis models. Its performance was evaluated against manually segmented images. A receiver’s operating characteristic curve was obtained for every image with regard to the different percentages of the image histogram. The area under the mean curve was 0.89 for the experimental angiogenesis model and 0.76 and 0.86 for the two clinical angiogenesis models. The coordinates of the operating point were 8.3% false positive rate and 92.8% true positive rate for the experimental model. Correspondingly for clinical angiogenesis models, the coordinates were 8.6% false positive rate and 89.2% true positive rate and 9.8% false positive rate and 93.8% true positive rate, respectively. A new user-friendly tool for the analysis of vascular networks in DSA images was developed that can be easily used in either experimental or clinical studies. Its main characteristics are robustness and fast and automatic execution.

Key words

DSA image processing quantification angiogenesis experimental  



Part of this work has been presented as poster presentation in the American Association of Physicists in Medicine 48th Annual Meeting in Orlando, FL.30 We thank the European Social Fund, Operational Program for Educational and Vocational Training II, and particularly the Program PYTHAGORAS II for funding the above work.

Supplementary material

10278_2007_9047_MOESM1_ESM.doc (712 kb)
ESM 1 (DOC 729 KB)


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Copyright information

© Society for Imaging Informatics in Medicine 2007

Authors and Affiliations

  • George C. Kagadis
    • 1
  • Panagiota Spyridonos
    • 1
  • Dimitris Karnabatidis
    • 2
  • Athanassios Diamantopoulos
    • 2
  • Emmanouil Athanasiadis
    • 1
  • Antonis Daskalakis
    • 1
  • Konstantinos Katsanos
    • 2
  • Dionisios Cavouras
    • 3
  • Dimitris Mihailidis
    • 4
  • Dimitris Siablis
    • 2
  • George C. Nikiforidis
    • 1
  1. 1.Department of Medical Physics, School of MedicineUniversity of PatrasRionGreece
  2. 2.Department of Radiology, School of MedicineUniversity of PatrasRionGreece
  3. 3.Department of Medical Instrumentation TechnologyTechnological Education Institute of AthensAthensGreece
  4. 4.Charleston Radiation Therapy ConsCharlestonUSA

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