Localizing Calcifications in Cardiac CT Data Sets Using a New Vessel Segmentation Approach
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The new generation of multislice computed tomography (CT) scanners allows for the acquisition of high-resolution images of the heart. Based on that image data, the heart can be analyzed in a noninvasive way—improving the diagnosis of cardiovascular malfunctions on one hand, and the planning of an eventually necessary intervention on the other. One important parameter for the evaluation of the severeness of a coronary artery disease is the number and localization of calcifications (hard plaques). This work presents a method for localizing these calcifications by employing a newly developed vessel segmentation approach. This extraction technique has been developed for, and tested with, contrast-enhanced CT data sets of the heart. The algorithm provides enough information to compute the vessel diameter along the extracted segment. An approach for automatically detecting calcified regions that combines diameter information and gray value analysis is presented. In addition, specially adapted methods for the visualization of these analysis results are described.
Key Words
Computed tomography vessel segmentation coronary arteries calcification image analysis visualizationNotes
Acknowledgements
This work has been partially funded by the German Federal Ministry of Education and Research (BMBF) project Medarpa (research grant 01IRA09B). We want to thank the Institute for Diagnostic and Interventional Radiology of the Johann Wolfgang Goethe University Frankfurt, Germany for providing us the cardiac CT data sets.
References
- 1.Rao, AV 2002Lycopene, tomatoes, and the prevention of coronary heart diseaseExp Biol Med227908913Google Scholar
- 2.Schussler, JM, Dockery, WD, Moore, TR, Johnson, KB, Rosenthal, RL, Stoler, RC 2005Computed tomographic coronary angiography: experience at Baylor University Medical Center/Baylor Jack and Jane Hamilton Heart and Vascular HospitalProc Bayl Univ Med Cent18228233PubMedGoogle Scholar
- 3.Agatston, AS, Janowitz, WR, Hildner, FJ, Zusmer, NR, Viamonte, M, Detrano, R 1990Quantification of coronary artery calcium using ultrafast computed tomographyJ Am Coll Cardiol15827832PubMedCrossRefGoogle Scholar
- 4.Becker, CR, Knez, A, Jakobs, TF, Aydemir, S, Becker, A, Schoepf, UJ, Bruening, R, Haberl, R, Reiser, MF 1999Detection and quantification of coronary artery calcification with electron-beam and conventional CTEur Radiol9620624PubMedCrossRefGoogle Scholar
- 5.Callister, TQ, Cooil, B, Raya, SP, Lippolis, NJ, Russo, DJ, Raggi, P 1998Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam CT volumetric methodRadiology208807814PubMedGoogle Scholar
- 6.Ohnesorge B, Flohr T.: Non-invasive cardiac imaging with fast multi-slice cardio CT. Electromedica 68:1–10, 2000. Spec issue Cardiology, Siemens AGGoogle Scholar
- 7.Taguchi, K, Anno, H 2000High temporal resolution for multislice helical computed tomographyMed Phys27861872PubMedCrossRefGoogle Scholar
- 8.Khan, MF, Herzog, C, Landenberger, K, Maataoui, A, Martens, S, Ackermann, H, Moritz, A, Vogl, TJ 2005Visualisation of non-invasive coronary by pass imaging: 4-row vs. 16-row multidetector computed tomographyEur Radiol15118126PubMedCrossRefGoogle Scholar
- 9.Kachelriess, M, Kalender, WA 1998Electrocardiogram-correlated image reconstruction from subsecond spiral computed tomography scans of the heartMed Phys2524172431PubMedCrossRefGoogle Scholar
- 10.Wang, G, Zhao, S, Heuscher, D 2002A knowledge-based cone-beam x-ray CT algorithm for dynamic volumetric cardiac imagingMed Phys2918071822PubMedCrossRefGoogle Scholar
- 11.Gerber, TC, Kuzo, RS, Karstaedt, N, Lane, GE, Morin, RL, Sheedy, PF, Safford, RE, Blackshear, JL, Pietan, JH 2002Current results and new developments of coronary angiography with use of contrast-enhanced computed tomography of the heartMayo Clin Proc775571PubMedCrossRefGoogle Scholar
- 12.Nieman K, Cademartiri F, Lemos PA, Raaijmakers R, Pattynama PMT, de Feyter PJ: Reliable noninvasive coronary angiography with fast submillimeter multislice spiral computed tomography. Circulation 106:2051–2054, American Heart Association, Inc. (2002) http://www.circulationaha.org. PubMedCrossRefGoogle Scholar
- 13.Traversi, E, Bertoli, G, Barazzoni, G, Baldi, M, Tramarin, R 2004Non-invasive coronary angiography with multislice computed tomography. Technology, methods, preliminary experience and prospectsItal Heart J58998PubMedGoogle Scholar
- 14.Dewey, M, Schnapauff, D, Laule, M, Lembcke, A, Borges, AC, Rutsch, W, Hamm, B, Rogalla, P 2004Multislice CT coronary angiography: evaluation of an automatic vessel detection toolFortschr Rontgenstr176478483CrossRefGoogle Scholar
- 15.Ropers D, Baum U, Pohle K, Anders K, Ulzheimer S, Ohnesorge B, Schlundt C, Bautz W, Daniel WG, Achenbach, S: Detection of coronary artery stenoses with thin-slice multi-detector row spiral computed tomography and multiplanar reconstruction. Circulation 107:664–666, 2003. American Heart Association, Inc. http://www.circulationaha.org.
- 16.Kirbas C, Quek KH: Vessel extraction techniques and algorithms: a survey. In: Bioinformatics and Bioengineering 2003. Proc. of the Third IEEE Symposium, 2003, pp 238–245Google Scholar
- 17.Yoo, TS (ed.): Insight Into Images. Peters, Ltd., 2004Google Scholar
- 18.Hennemuth A, Boskamp T, Fritz D, Kühnel C, Bock S, Rinck D, Scheuering M, Peitgen HO: One-click coronary tree segmentation in CT angiographic images. In: Lemke, HU (ed.) Computer Assisted Radiology and Surgery. Proc. Of the 19th CARS 2005, Elsevier, 2005, pp 317–321Google Scholar
- 19.Sorantin, E, Halmai, C, Erdöhely, B, Palágyi, K, Nyúl, L, Ollé, K, Geiger, B, Lindbichler, F, Friedrich, G, Kiesler, K 2002Spiral-CT-based assessment of tracheal stenoses using 3-D-skeletonizationIEEE Trans Med Imag21263273CrossRefGoogle Scholar
- 20.Verdonck B, Bloch I, Maître H, Vandermeulen D, Suetens P, Marchal G: Blood vessel segmentation and visualization in 3D MRand spiral CT angiography. In: Lemke, HU (ed.) Computer Assisted Radiology. Proc. of the CAR 1995, Springer, 1995, pp 177–182Google Scholar
- 21.Wesarg S, Firle EA: Segmentation of vessels: the corkscrew algorithm. In: Robert, L, Galloway, JE (eds.) Medical Imaging Symposium 2004. Volume 5370 of Proc. of SPIE. 2004, pp 1609–1620Google Scholar
- 22.Fleischmann, D 2003High-concentration contrast media in MDCT angiography: principles and rationaleEur Radiol133943Google Scholar
- 23.Flohr, T, Ohnesorge, B 2001Heart rate adaptive optimization of spatial and temporal resolution for electrocardiogram-gated multislice spiral CT of the heartJ Comput Assist Tomogr25907923PubMedCrossRefGoogle Scholar
- 24.Schroeder W, Martin K, Lorensen B: The Visualization Toolkit—An Object-Oriented Approach to 3D Graphics. 3rd edn. Kitware, Inc., 2002Google Scholar