Creation of a CT Image Library for the Lung Screening Study of the National Lung Screening Trial
The CT Image Library (CTIL) of the Lung Screening Study (LSS) network of the National Lung Screening Trial (NLST) consists of up to three annual screens using CT imaging from each of 17,308 participants with a significant history of smoking but no evidence of cancer at trial enrollment (Fall 2002–Spring 2004). Screens performed at numerous medical centers associated with 10 LSS-NLST screening centers are deidentified of protected health information and delivered to the CTIL via DVD, external hard disk, or Internet/Virtual Private Network transmission. The collection will be completed in late 2006. The CTIL is of potential interest to clinical researchers and software developers of nodule detection algorithms. Its attractiveness lies in its very specific, well-defined patient population, scanned via a common CT protocol, and in its collection of evenly spaced serial screens. In this work, we describe the technical details of the CTIL collection process from screening center retrieval through library storage.
Key WordsCT image library NLST NCI CTIL clinical trial lung cancer
- 1.Gohagan JK, Prorok PC, Hayes RB, Kramer BS, and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Project Team: The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial of the National Cancer Institute: history, organization and status. Control Clin Trials 21 (6 Suppl):251S–272S, December 2000CrossRefGoogle Scholar
- 2.Moore, SM Gierada, DS Clark, KW Blaine, GJ The PLCO-NLST Quality Assurance Working Group2005Image quality assurance in the Prostate, Lung, Colon, and Ovarian (PLCO) cancer screening trial network of the national lung screening trial. SCAR-2004, Poster SessionJ Digit Imaging18242250PubMedCrossRefGoogle Scholar
- 3.Moore SM, Maffitt DR, Blaine GJ, Bae KT: A workstation acquisition node for multi-center imaging studies. Proceedings of SPIE, Medical Imaging 2001, PACS and Integrated Medical Information Systems: Design and Evaluation 4323:271–277, 2001Google Scholar