, Volume 53, Issue 1, pp 36–39 | Cite as

Gamma-aminobutyric acid (GABA) increases in vitro germ-tube formation and phospholipase B1 mRNA expression in Candida albicans

  • María Guadalupe Reyes-García
  • Francisca Hernández-Hernández
  • Fernando García-Tamayo
Short Communication


Candida albicans is a commensal yeast in humans that disseminates in immunocompromised persons. Its spreading is modulated by melanin, hormones, or some neurotransmitters, among other factors. The neurotransmitter gamma-aminobutyric acid (GABA) is used by bacteria, plants, and fungi as a carbon and nitrogen source. In this article, the in vitro effect of different doses of GABA on germ-tube formation and expression of phospholipase B1 (PLB1) mRNA in two Candida albicans strains was investigated. Results demonstrated that GABA increases both germ-tube formation and PLB1 mRNA expression in the two Candida strains in a dose-dependent manner, which suggests that GABA promotes the growth of C. albicans.


Germ tubes Neurotransmitter RT-PCR Virulence factors Yeasts 



We thank Joseph Doshner-Maute for correcting the English version of the manuscript. The authors have no conflict of interest. We declare that all experiments in this paper comply with the current laws of Mexico.


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Copyright information

© The Mycological Society of Japan and Springer 2011

Authors and Affiliations

  • María Guadalupe Reyes-García
    • 1
  • Francisca Hernández-Hernández
    • 2
  • Fernando García-Tamayo
    • 1
  1. 1.Laboratorio de Inmunobiología, Departamento de Biología. Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoMexicoMexico
  2. 2.Laboratorio de Micología Médica Molecular, Departamento de Microbiología y Parasitología, Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexicoMexico

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