, Volume 107, Issue 1, pp 37–45 | Cite as

Generation and histomorphometric evaluation of a novel fluvastatin-containing poly(lactic-co-glycolic acid) membrane for guided bone regeneration

  • Haomiao Zhang
  • Yasuko MoriyamaEmail author
  • Yasunori Ayukawa
  • Yunia Dwi Rakhmatia
  • Yoko Tomita
  • Noriyuki Yasunami
  • Kiyoshi Koyano
Original Article


The purpose of this study was to evaluate the effects of a poly(lactic-co-glycolic acid) (PLGA) membrane containing fluvastatin on bone regeneration at bone defects in rat calvaria and tibia for possible use as a guided bone regeneration (GBR) membrane. PLGA and fluvastatin-containing PLGA (PLGA–fluvastatin) membranes were prepared and mechanical properties were evaluated. Standardized bony defects were created in rat calvaria and the right tibia, and covered with a PLGA or PLGA–fluvastatin membrane. Bone regeneration was evaluated using image analysis based on histologic examination. At 4 and 8 weeks after membrane implantation, the PLGA–fluvastatin group displayed enhanced new bone formation around the edge of the defect compared with the PLGA membrane group in the calvarial model. Thick bone regeneration was observed in tibia-defect sites in the PLGA–fluvastatin membrane group. These results suggest that the PLGA-containing fluvastatin membrane prepared in this study may potentially be used as a GBR membrane.


Guided bone regeneration (GBR) Poly(lactic-co-glycolic acid) (PLGA) membrane Statin Osteoconductive Histomorphometric 



This study was supported in part by KAKENHI (no. 15H06490) from the Japan Society for the Promotion of Science.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© The Society of The Nippon Dental University 2018

Authors and Affiliations

  • Haomiao Zhang
    • 1
  • Yasuko Moriyama
    • 1
    Email author
  • Yasunori Ayukawa
    • 1
  • Yunia Dwi Rakhmatia
    • 1
  • Yoko Tomita
    • 1
  • Noriyuki Yasunami
    • 1
  • Kiyoshi Koyano
    • 1
  1. 1.Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental ScienceKyushu UniversityFukuokaJapan

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