, Volume 107, Issue 1, pp 90–95 | Cite as

Association between periodontitis and chronic migraine: a case–control study

  • Pablo Ameijeira
  • Yago LeiraEmail author
  • Clara Domínguez
  • Rogelio Leira
  • Juan Blanco
Original Article


The aim of this investigation was to examine whether chronic periodontitis (CP) is a risk indicator of chronic migraine (CM). We performed a case–control study consisted of 102 cases (patients diagnosed with CM) and 91 controls (non-CM individuals) matched by age and gender. Full-mouth periodontal charts, demographic, medical, clinical, as well as neurological data were obtained. In addition, high sensitive C-reactive protein serum levels were determined from blood samples of both cases (taken during migraine interictal period) and controls. The prevalence of CP was significantly higher in patients with CM compared to those without CM (58.8 vs. 30.8%, p < 0.0001). Logistic regression analysis showed that CP was significantly associated with the presence of CM, independently of well-known chronifying factors of migraine (OR 2.4; 95% CI 1.2–4.7; p = 0.012). Based on our results, CP could be considered as a risk indicator of CM. However, more evidence is necessary to investigate if this relationship is causal or not.


Periodontitis Migraine Headache Risk factors Chronification 



Y. Leira is supported by a fellowship from the Health Research Institute of Santiago de Compostela (IDIS) and is the recipient of the 2017 SEPA-Sunstar International Training Grant.


This study was partially supported by grants from the Spanish Ministry of Economy and Competitiveness—Institute of Health Carlos III (PI15/01578). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest in relation to this paper.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© The Society of The Nippon Dental University 2018

Authors and Affiliations

  1. 1.Periodontology Unit, Faculty of Medicine and OdontologyUniversity of Santiago de CompostelaSantiago de CompostelaSpain
  2. 2.Odontología Médico-Quirúrgica (OMEQUI) Research GroupHealth Research Institute of Santiago de Compostela (IDIS)Santiago de CompostelaSpain
  3. 3.Headache Unit, Department of Neurology, Hospital Clínico UniversitarioUniversity of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)Santiago de CompostelaSpain

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