Odontology

, Volume 104, Issue 3, pp 329–337 | Cite as

Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes

  • Siriporn Songsiripradubboon
  • Wijit Banlunara
  • Polkit Sangvanich
  • Chutima Trairatvorakul
  • Pasutha Thunyakitpisal
Original Article
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Abstract

Acemannan has been previously reported as a direct pulp-capping agent in animal study. This natural material demonstrated its biocompatibility and enhanced reparative dentin formation. The objective of this study was to investigate the action of acemannan as a direct pulp-capping material in human primary teeth with deep caries. Forty-two deeply carious mandibular primary molars from 37 children, aged 7–11 years old diagnosed with reversible pulpitis were studied. After completely removing the infected dentine, teeth with a pinpoint pulpal exposure were randomly divided into two treatment groups: acemannan or calcium hydroxide. A glass-ionomer cement base was applied to all teeth prior to restoration with stainless steel crowns. Clinical and radiographic evaluation was performed 6 months post-treatment. The teeth due to exfoliate were extracted and histopathologically evaluated for inflammation, dentine bridge formation, and soft tissue organization. At 6 months, the overall clinical and radiographic success rates of direct pulp capping with acemannan and calcium hydroxide at 6 months were 72.73 and 70.0 %, respectively. The histopathological results indicated that the acemannan-treated group had significantly better histopathological responses compared with the calcium hydroxide-treated group (p < 0.05). These data suggest acemannan offers a valuable alternative biomaterial for vital pulp therapy in primary teeth.

Keywords

Acemannan Aloe vera Biomaterial Clinical study Histopathological evaluation Vital pulp therapy 
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Notes

Acknowledgments

We thank Professor Dr. Visaka Limwong, Associate Professor Dr. Dolly Methatharathip, and Dr. Kevin A. Tompkins for their valuable suggestions and Associate Professor Dr. Sommai Chobisara for radiographic evaluation. This work was supported by National Research Council of Thailand, Cerebos Awards 2010, and the 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund).

Compliance with ethical standards

Conflict of interest

No conflicts of interest exist.

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Copyright information

© The Society of The Nippon Dental University 2015

Authors and Affiliations

  • Siriporn Songsiripradubboon
    • 1
    • 2
  • Wijit Banlunara
    • 3
  • Polkit Sangvanich
    • 4
  • Chutima Trairatvorakul
    • 2
  • Pasutha Thunyakitpisal
    • 5
  1. 1.Dental Biomaterials Science Program, Graduate SchoolChulalongkorn UniversityBangkokThailand
  2. 2.Department of Pediatric Dentistry, Faculty of DentistryChulalongkorn UniversityBangkokThailand
  3. 3.Department of Pathology, Faculty of Veterinary ScienceChulalongkorn UniversityBangkokThailand
  4. 4.Department of Chemistry, Faculty of ScienceChulalongkorn UniversityBangkokThailand
  5. 5.Research Unit of Herbal Medicine, Biomaterial, and Material for Dental Treatment, Department of Anatomy, Faculty of DentistryChulalongkorn UniversityBangkokThailand

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