Clinical and Experimental Medicine

, Volume 3, Issue 1, pp 1–3 | Cite as

DNA microarrays in clinical practice: past, present, and future

  • N. Sevenet
  • O. Cussenot
REVIEW

Abstract.

Gene expression is a central concept in molecular biology and forms part of our knowledge of the role of genes in human diseases. Genome-wide monitoring of gene expression using DNA microarrays (allowing the simultaneous assessment of the transcription of tens of thousands of genes, and of their relative expression between normal cells and pathological cells) represents one of the latest breakthroughs in experimental molecular biology and provides unprecedented opportunity to explore the biological processes underlying human diseases by providing a comprehensive survey of a cell's transcriptional landscape. This revolutionary technology ultimately leads to the discovery of new biomarkers for disease diagnosis and prognosis prediction, and of new therapeutic tools. This paper provides an overview of microarray technology and describes some of its recent applications in medicine.

Key words Microarray Gene expression Prognosis Prediction 

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Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • N. Sevenet
    • 1
  • O. Cussenot
    • 2
  1. 1.Plateforme de Génomique, Service de Biochimie et de Biologie Moléculaire, Hôpital Lariboisière (AP-HP), 2, rue Ambroise Paré, F-75010 Paris, France. nicolas.sevenet@lrb.ap-hop-paris.frFR
  2. 2.CeRePP-EA3104, Université Paris VII, Génopôle, and Département d'Urologie, Hôpital Tenon (AP-HP), 75020 Paris, FranceFR

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