Prevalence and characteristics of arthritis in Kawasaki disease: a Chinese cohort study
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Arthritis is a major complication of Kawasaki disease (KD). The aims of this study were to define the frequency and the clinical characteristics of arthritis in KD in China and to analyze the relation between arthritis and coronary outcome in KD. We included 1420 KD patients followed at Jiangxi Children’s Hospital from January 2014 to December 2017. Demographic, clinical and laboratory features of KD were analyzed. Among the 1420 patients enrolled, 151 had arthritis. The median age of KD patients with arthritis was 29 months and older than those without arthritis (20 months). Of the 151 patients developed arthritis, 101 patients (66.9%) had oligoarticular involvement and 50 patients (33.1%) had polyarticular involvement. Early-onset and late-onset arthritis were, respectively, observed in 123 (81.45%) and 28 (18.54%) patients. The KD patients with arthritis had significantly increased levels of inflammatory markers, and we observed a higher incidence rate of coronary artery aneurysms among those with arthritis (7.28%) compared to those without arthritis (2.75%) (p = 0.003), but the prevalence of coronary artery lesions (CALs) was similar in the two groups. The arthritis in KD was self-limited, left no sequelae and did not require additional medications. KD patients with arthritis were more likely to get coronary artery aneurysms than the patients without arthritis, so examination of joints in KD was necessary.
KeywordsKawasaki disease (KD) Arthritis Coronary artery lesions (CALs) Articular outcome
This work was supported by the Natural Science Foundation of Jiangxi Province under Grant No. 20122BAB205085 and the Health Committee Foundation of Jiangxi Province under Grant No. 20185445.
ZZ and YZ contributed to the study design. YP organized the study and performed the writing of the manuscript. YP and YZ performed the statistical analysis. XL, ZD, YD, SC, ZW, KX, HK, MJ and LL performed the data entry. All authors have participated in the discussion of the manuscript and approved the final version of the manuscript.
This study was funded by the Natural Science Foundation of Jiangxi Province (Grant Number 20122BAB205085 to Prof. Zou) and the Health Committee Foundation of Jiangxi Province (Grant Number 20185445 to Dr. Peng).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The study protocol was approved by the Ethics Committee of Jiangxi Province Children’s Hospital.
For this type of study, formal consent is not required.
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