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Meta-analysis of FOLFIRINOX regimen as the first-line chemotherapy for locally advanced pancreatic cancer and borderline resectable pancreatic cancer

  • Xifeng Xu
  • Qiong Wu
  • Zhen Wang
  • Song Zheng
  • Ke Ge
  • Changku Jia
Original Article

Abstract

The study aimed to evaluate the effectiveness of the first-line chemotherapy FOLFIRINOX in treating pancreatic cancer. Pertinent studies were derived from the PubMed, Cochrane Library and EMBASE. The outcomes were analyzed according to resection rate and radical (R0) resection rate. Data were expressed as weighted commix proportions with 95% confidence intervals (CIs). Twenty-three studies, involving 968 patients with locally advanced pancreatic cancer (LAPC) and borderline resectable pancreatic cancer (BRPC), were examined. After treatment, 55% (95% CI 52–58%) of the patients underwent resection and 40% (95% CI 37–43%) underwent R0 resection, and the median overall survival ranged from 15.5 to 35.4 months, with a 10.0–27.1 months’ median progression-free survival. The meta-analysis shows that FOLFIRINOX, as the first-line therapy, has significant down-staging effects in patients with LAPC or BRPC, with a 40% R0 resection rate and the adverse events under control.

Keywords

Pancreatic cancer FOLFIRINOX Resection 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Medical Oncology, Hangzhou First People’s HospitalNanjing Medical UniversityHangzhouChina
  2. 2.Department of Hepatobiliary SurgeryHangzhou First People’s HospitalHangzhouChina
  3. 3.Department of Medical Oncology, Hangzhou First People’s Hospital, Nanjing Medical University, Hangzhou Cancer HospitalZhejiang Chinese Medical University Affiliated Hangzhou First HospitalHangzhouChina

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