Clinical and Experimental Medicine

, Volume 17, Issue 4, pp 451–457 | Cite as

Relationship between IL-27 and coronary arterial lesions in children with Kawasaki disease

  • Feifei Si
  • Yao Wu
  • Fang Gao
  • Siqi Feng
  • Ruixi Liu
  • Qijian Yi
Original Article


Kawasaki disease (KD) arises due to the disorder of the inflammation response and faulty immune regulation. Interleukin-27 (IL-27) is a novel cytokine with both pro-inflammatory and anti-inflammatory effects. This study investigated the relationship between serum levels of IL-27, Interleukin-17A (IL-17A), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and coronary artery lesions (CALs) in patients with KD. We obtained blood samples from 81 children with KD before intravenous immunoglobulin (IVIG) therapy. Levels of IL-27, IL-17A, IL-10, IL-6, IL-1β and TNF-α were measured in 251 cases, including 4 groups: the normal control group, NC (n = 90), febrile control, FC (n = 80), KD without coronary arteries (n = 41) and KD with coronary arterial lesions (n = 40). White blood cells counts (WBC), red blood cells counts (RBC), hemoglobin, C-reactive protein (CRP), erythrocyte sedimentation rate and procalcitonin (PCT) were tested in all subjects. Levels of IL-27, IL-10, IL-17A, IL-6, IL-1β and TNF-α were significantly elevated, and RBC and hemoglobin significantly decreased in the group of KD group compared with febrile and control groups. IL-27, IL-6, IL-1β and TNF-α serum levels are even higher in KD children with CALs. There was positive relationship between serum levels of IL-27 and WBC, CRP, PCT, IL-10, IL-17A, IL-6 and TNF-α in children with KD. The up-regulation of IL-27 may be closely linked to up-regulation of systemic pro-inflammatory markers in acute KD. Morover, IL-27 may be involved in the development of CALs in acute KD.


Kawasaki disease (KD) Interleukin-27 (IL-27) Interleukin-17A (IL-17A) Interleukin-10 (IL-10) Coronary arterial lesion 



This work was supported by National Natural Science Foundation of China under Grant: No. 81270412 and National Natural Science Foundation of China under Grant: No. 81500273.

Compliance with ethical standards

Conflict of interest

All authors have no actual or potential conflicts of interest with other people or organizations with 3 years of initiating the work presented here.

Ethical approval

The study protocol was approved by the Ethics Committee of Children’s Hospital of Chongqing Medicine University, and written informed consent forms were obtained from the parents of all subjects.


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Key Laboratory of Pediatrics in ChongqingChongqingPeople’s Republic of China
  2. 2.Chongqing International Science and Technology Cooperation Center for Child Development and DisordersChongqingPeople’s Republic of China
  3. 3.Department of Cardiovascular MedicineChildren’s Hospital of Chongqing Medical UniversityChongqingPeople’s Republic of China

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