Clinical and Experimental Medicine

, Volume 14, Issue 3, pp 345–353 | Cite as

Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer

  • Dong Hoon Suh
  • Min A. Kim
  • Haeryoung Kim
  • Mi-Kyung Kim
  • Hee Seung Kim
  • Hyun Hoon Chung
  • Yong-Beom Kim
  • Yong Sang Song
Original Article


This aim of this study was to evaluate the relationship between hexokinase II expression and chemoresistance in epithelial ovarian cancer. One hundred and eleven paraffin-embedded specimens from patients with epithelial ovarian cancer were immunohistochemically stained for hexokinase II. Subsequently, the association between hexokinase II overexpression and clinicopathologic characteristics including chemoresistance was assessed. Survival analyses were also performed for evaluating the prognostic value of hexokinase II overexpression. Tumor recurrence within 6 months after termination of first-line chemotherapy was considered to indicate chemoresistance. Hexokinase II overexpression was associated with chemoresistance (p = 0.029) and was an independent risk factor for chemoresistance [odds ratio (OR) 3.37; 95 % confidence interval (CI) 1.07–10.62; p = 0.038] along with non-optimal debulking surgery (OR 4.93; 95 % CI 1.43–16.98; p = 0.011). Hexokinase II overexpression was significantly associated with decreased progression-free survival (p = 0.002) and showed a similar trend for overall survival (p = 0.101). Cox regression analysis revealed that hexokinase II overexpression was an independent prognostic factor for early recurrence (hazard ratio 2.63; 95 % CI 1.40–4.92; p = 0.002). Our findings suggest that hexokinase II overexpression is associated with short progression-free survival, which could be associated with chemoresistance in epithelial ovarian cancer.


Hexokinase Immunohistochemistry Drug resistance Recurrence Ovarian cancer 



This work was supported by grant from the SNUH Research Fund (No. 0320120350). This research was also supported by Basic Science Research Program (No. 2011-0025394), WCU (World Class University) program (R31-10056), and Priority Research Centers Program (No. 2009-0093820) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology.

Conflict of interest

The authors indicate no potential conflict of interest.


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Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • Dong Hoon Suh
    • 1
    • 7
  • Min A. Kim
    • 2
  • Haeryoung Kim
    • 3
  • Mi-Kyung Kim
    • 1
  • Hee Seung Kim
    • 1
  • Hyun Hoon Chung
    • 1
  • Yong-Beom Kim
    • 4
  • Yong Sang Song
    • 1
    • 5
    • 6
  1. 1.Department of Obstetrics and GynecologySeoul National University College of MedicineSeoulKorea
  2. 2.Department of PathologySeoul National University College of MedicineSeoulKorea
  3. 3.Department of PathologySeoul National University Bundang HospitalSeongnamKorea
  4. 4.Department of Obstetrics and GynecologySeoul National University Bundang HospitalSeongnamKorea
  5. 5.Cancer Research InstituteSeoul National University College of MedicineSeoulKorea
  6. 6.WCU Biomodulation Major, Department of Agricultural BiotechnologySeoul National UniversitySeoulKorea
  7. 7.Department of Obstetrics and GynecologySeoul National University Bundang HospitalSeongnamKorea

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