Clinical and Experimental Medicine

, Volume 14, Issue 1, pp 13–24 | Cite as

Therapeutic application of mesenchymal stem cells in bone and joint diseases

Review Article


Mesenchymal stem cells (MSCs), the non-hematopoietic progenitor cells, are multi-potent stem cells from a variety of tissues with the capability of self-renewal, proliferation, differentiation into multi-lineage cell types, as well as anti-inflammatory and immunomodulatory. These properties make MSCs an ideal source of cell therapy in bone and joint diseases. This review describes the advances of animal study and preliminary clinical application in the past few years, related to MSC-based cell therapy in the common bone and joint diseases, including osteoarthritis, rheumatoid arthritis, osteoporosis, osteonecrosis of the femoral head and osteogenesis imperfecta. It highlights the promising prospect of MSC in clinical application of bone and joint diseases.


Mesenchymal stem cells (MSCs) Osteoarthritis (OA) Osteogenesis imperfecta (OI) Osteoporosis Osteonecrosis of the femoral head (ONFH) Rheumatoid arthritis (RA) 


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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  1. 1.Jinan Pediatric Research InstituteQilu Children’s Hospital of Shandong UniversityJinanChina
  2. 2.Key Laboratory for Biotech-Drugs of the Ministry of Health, Shandong Medicinal Biotechnology CenterShandong Academy of Medical SciencesJinanChina

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