Clinical and Experimental Medicine

, Volume 13, Issue 4, pp 257–263

Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy

  • Hasibe Artac
  • Reyhan Kara
  • Bahar Gokturk
  • Ismail Reisli
Original Article

DOI: 10.1007/s10238-012-0200-y

Cite this article as:
Artac, H., Kara, R., Gokturk, B. et al. Clin Exp Med (2013) 13: 257. doi:10.1007/s10238-012-0200-y

Abstract

We aimed to evaluate the role of the CD19 complex in the pathogenesis of transient hypogammaglobulinemia of infancy (THI) and to better characterize the subsets of memory B cells. The study population consisted of 22 male and 14 female patients with a mean age at presentation of 20 ± 9.9 months. The CD19 complex and B cell subsets were evaluated by flow cytometry. While the CD19 median fluorescence index (MFI) in patients with THI was significantly lower than controls (122.9 ± 66.7 in patients; 184.2 ± 39 in controls, p < 0.01), expression of CD21 and CD81 was increased (94.4 ± 3, 96.8 ± 2.5 % in patients; 91 ± 3.9; 94.7 ± 3.5 % in controls, p < 0.01 vs. p < 0.05, respectively). The expressions of switched memory B cells and IgM memory B cells were found to be reduced in THI. Considering that the CD19 complex regulates the events following antigen stimulation, the change in CD19 complex detected in THI may be related to insufficiency of antibody production.

Keywords

Transient hypogammaglobulinemia of infancy CD19 complex Memory B cells 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Hasibe Artac
    • 1
  • Reyhan Kara
    • 1
  • Bahar Gokturk
    • 2
  • Ismail Reisli
    • 2
  1. 1.Department of Pediatric Immunology and AllergySelcuk University Selcuklu Medical FacultyKonyaTurkey
  2. 2.Department of Pediatric Immunology and AllergyNecmettin Erbakan University Meram Medical FacultyKonyaTurkey

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