Clinical and Experimental Medicine

, Volume 13, Issue 3, pp 225–227 | Cite as

Granulomatous skin lesions in a renal transplant patient

  • Domenico BonamonteEmail author
  • Caterina Foti
  • Nicoletta Cassano
  • Michelangelo Vestita
  • Paolo Greco
  • Antonietta Cimmino
  • Gino Antonio Vena
Letter to the Editor

In April 2011, a 54-year-old male from Southern Italy presented with multiple asymptomatic nodular lesions involving the lower limbs. He reported some of these nodules had appeared 5 months earlier, while others, of which many had resolved, dated back in time 3–4 years. Treatment with topical antibiotics and corticosteroids repeatedly failed to cause any evident improvement of these lesions. Patient’s history revealed the presence of arterial hypertension, ulcerative colitis since 1981, and nephrotic syndrome secondary to mesangial glomerulonephritis, since 1976, which led him to hemodialysis at first and eventually to bilateral kidney transplantation in 2001. Consequently, the patient took the following medications mesalazine, methylprednisolone, azathioprine, tacrolimus, propranolol and amlodipine.

On physical examination, there were a solitary pink-colored nodule on the right ankle area and a few discrete lesions on the left knee, presenting as violaceous, indurated nodules and...


Nephrotic Syndrome Mesalazine Granuloma Annulare Angiolymphoid Hyperplasia Eosinophilic Abscess 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest

The authors declare no conflict of interest.


  1. 1.
    Jani A, Coulson M (1997) Kimura’s disease: a typical case of a rare disorder. West J Med 166:142–144PubMedGoogle Scholar
  2. 2.
    Lenk N, Artuz F, Kulacoglu S, Alli N (1997) Kimura’s disease. Int J Dermatol 36:437–439PubMedCrossRefGoogle Scholar
  3. 3.
    Kimura Y, Pawankar R, Aoki M, Niimi Y, Kawana S (2002) Mast cells and T cells in Kimura’s disease express increased levels of interleukin-4, interleukin-5, eotaxin and RANTES. Clin Exp Allergy 32:1787–1793PubMedCrossRefGoogle Scholar
  4. 4.
    Ohta N, Fukase S, Suzuki Y, Ito T, Yoshitake H, Aoyagi M (2011) Increase of Th2 and Tc1 cells in patients with Kimura’s disease. Auris Nasus Larynx 38:77–82PubMedCrossRefGoogle Scholar
  5. 5.
    Wang YS, Tay YK, Tan E, Poh WT (2005) Treatment of Kimura’s disease with cyclosporine. J Dermatol Treat 16:242–244CrossRefGoogle Scholar
  6. 6.
    Chun SI, Ji HG (1992) Kimura’s disease and angiolymphoid hyperplasia with eosinophilia: clinical and histopathologic differences. J Am Acad Dermatol 27:954–958PubMedCrossRefGoogle Scholar
  7. 7.
    Seregard S (2001) Angiolymphoid hyperplasia with eosinophilia should not be confused with Kimura’s disease. Acta Ophthalmol Scand 79:91–93PubMedCrossRefGoogle Scholar
  8. 8.
    Guimaraes CS, Moulton-Levy N, Sapadin A, Vidal C (2009) Kimura’s Disease. Case Report Med 2009:424053Google Scholar
  9. 9.
    Tsukagoshi H, Nagashima M, Horie T, Oyama T, Yoshii A, Sato T, Iizuka K, Dobashi K, Mori M (1998) Kimura’s disease associated with bronchial asthma presenting eosinophilia and hyperimmunoglobulinemia E which were attenuated by suplatast tosilate (IPD-1151T). Intern Med 37:1064–1067PubMedCrossRefGoogle Scholar
  10. 10.
    Liu H, Al-Quran SZ, Lottenberg R (2010) Thrombotic storm in Kimura disease. J Thromb Thrombolysis 29:354–357PubMedCrossRefGoogle Scholar
  11. 11.
    Danis R, Ozmen S, Akin D, Ozekinci S, Altintas A, Cil T, Pasa S, Kilinc I (2009) Thrombosis of temporal artery and renal vein in Kimura-disease-related nephrotic syndrome. J Thromb Thrombolysis 27:115–118PubMedCrossRefGoogle Scholar
  12. 12.
    Tamaki T, Yoji N (2010) Occlusion of internal carotid artery in Kimura’s disease. Case Report Med 2010:407538Google Scholar
  13. 13.
    Rajpoot DK, Pahl M, Clark J (2000) Nephrotic syndrome associated with Kimura disease. Pediatr Nephrol 14:486–488PubMedCrossRefGoogle Scholar
  14. 14.
    Usha KS, Singh RG, Tapas S, Prakash J, Garbyal RS (2008) Mesangioproliferative glomerulonephritis: an important glomerulonephritis in nephrotic syndrome of young adult. Indian J Pathol Microbiol 51:337–341PubMedCrossRefGoogle Scholar
  15. 15.
    Sugaya M, Suzuki T, Asahina A, Nakamura K, Ohtsuki M, Tamaki K (1998) Kimura’s disease associated with ulcerative colitis: detection of IL-5 mRNA expression of peripheral blood mononuclear cells and colon lesion. Acta Derm Venereol 78:375–377PubMedCrossRefGoogle Scholar
  16. 16.
    Shimamoto C, Takao Y, Hirata I, Ohshiba S (1993) Kimura’s disease (angiolymphoid hyperplasia with eosinophilia) associated with ulcerative colitis. Gastroenterol Jpn 28:298–303PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Domenico Bonamonte
    • 1
    Email author
  • Caterina Foti
    • 1
  • Nicoletta Cassano
    • 1
  • Michelangelo Vestita
    • 1
  • Paolo Greco
    • 1
  • Antonietta Cimmino
    • 2
  • Gino Antonio Vena
    • 1
  1. 1.Unit of Dermatology and Venereology, Department of Biomedical Sciences and Human OncologyUniversity of BariBariItaly
  2. 2.Department of Pathological AnatomyUniversity of BariBariItaly

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