Clinical and Experimental Medicine

, Volume 13, Issue 1, pp 59–65

Kidney post-transplant monitoring of urinary glycosaminoglycans/proteoglycans and monokine induced by IFN-γ (MIG)

  • Pierina De Muro
  • Rossana Faedda
  • Antonio Masala
  • Antonio Junior Lepedda
  • Elisabetta Zinellu
  • Milco Ciccarese
  • Maria Cossu
  • Pier Giorgio Pala
  • Rita Pasqualina Satta
  • Marilena Formato
Original Article

Abstract

Allograft rejection during the first year after renal transplantation can lead to persistent allograft dysfunction and reduced long-term graft survival. Thus, it is important to define early predictors of kidney damage, less invasive than allograft biopsy. Urinary glycosaminoglycan/proteoglycan concentration and distribution, N-acetyl-β-(d)-glucosaminidase (NAG), and monokine induced by IFN-γ (MIG) levels were evaluated in the immediate post-transplant and during a 1-year follow-up. We observed increased urinary levels of MIG, urinary trypsin inhibitor and its degradation products, the lack of urinary heparan sulfate excretion, and the decreased chondroitin sulfate relative content at day 1 post-transplant in most patients who developed complications in the postoperative period. Moreover, urinary MIG levels showed significant correlations with NAG, C-reactive protein, and GFR at day 1 post-transplant. The monitoring of glycosaminoglycan/proteoglycan urinary pattern and the levels of urine MIG could serve as useful markers for predicting possible complications of transplantation, unraveling an early inflammatory state, on whose basis the immunosuppressive therapy could be appropriately modified.

Keywords

Glycosaminoglycans Kidney transplantation Monokine induced by IFN-γ Proteoglycans Urinary trypsin inhibitor 

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Pierina De Muro
    • 1
  • Rossana Faedda
    • 2
  • Antonio Masala
    • 2
  • Antonio Junior Lepedda
    • 1
  • Elisabetta Zinellu
    • 1
  • Milco Ciccarese
    • 3
  • Maria Cossu
    • 3
  • Pier Giorgio Pala
    • 3
  • Rita Pasqualina Satta
    • 3
  • Marilena Formato
    • 1
  1. 1.Department of Physiological, Biochemical and Cellular SciencesUniversity of SassariSassariItaly
  2. 2.Department of Clinical and Medical PathologyUniversity of SassariSassariItaly
  3. 3.Nephrology, Dialysis and Transplantation UnitAzienda Sanitaria Locale di SassariSassariItaly

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