Clinical and Experimental Medicine

, Volume 10, Issue 2, pp 129–134 | Cite as

Empty sella and primary autoimmune hypothyroidism

  • Rogelio García-Centeno
  • José Pablo Suárez-Llanos
  • Elisa Fernández-Fernández
  • Victor Andía-Melero
  • Petra Sánchez
  • Antonino Jara-Albarrán
Original Article


In order to assess the association between empty sella (ES) and primary autoimmune hypothyroidism, and the possibility of a common pathogenesis. We retrospectively studied all patients with presumed ES diagnosed in the last 20 years, most of whom were treated by our Endocrinology Department. Subjects with a known etiology were excluded. Incomplete records or those with a doubtful diagnosis were also excluded. A total of 56 subjects were included in the study. ES was diagnosed by pituitary MRI. The measurement of free T4, TSH, and antithyroid antibodies (TPOAb and TgAb) was assayed using commercial kits. The cases of hypothyroidism obtained were compared with those in another group of similar patients, diagnosed with diabetes mellitus type 2, through χ2 test. A total of 15 (26.78%) patients of 56 with ES had autoimmune thyroid disease (subclinical or clinical hypothyroidism). Primary hypothyroidism with negative antithyroid autoantibodies was found in a further 13 patients (23.21%). The 46.42% of ES had primary hypothyroidism; this result had obtained a statistically significant difference when compared to the ratio obtained in the group of diabetes mellitus type 2 (P < 0.0029). There is an important association between ES and autoimmune thyroid disease, which reached 26.78% in our series. We suggest the possibility of a common pathogenesis for certain cases of ES and autoimmune thyroid disease, with the end point of ES in the pituitary, and atrophy in the thyroid gland.


Empty sella syndrome Hypothyroidism Autoimmune diseases 


Conflict of interest statement

Every author has participated sufficiently in the work to take public responsibility for its content.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Rogelio García-Centeno
    • 1
  • José Pablo Suárez-Llanos
    • 1
  • Elisa Fernández-Fernández
    • 1
  • Victor Andía-Melero
    • 1
  • Petra Sánchez
    • 1
  • Antonino Jara-Albarrán
    • 1
  1. 1.Department of EndocrinologyHospital General Universitario Gregorio MarañónMadridSpain

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