Serum levels of angiogenic cytokines decrease after radiotherapy in non-Hodgkin lymphomas
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Serum levels of angiogenic cytokines decrease after radiotherapy in patients with cancer, and this may be relevant for treatment response and progression-free survival. Herein, we set out to determine whether circulating fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF) and platelet-derived growth factor-β (PDGF-β) decrease after radiotherapy in patients with non-Hodgkin lymphomas (NHLs) and if so, whether their decrease correlates with age, tumour histotype and stage, and radiation dose.
Material and methods
The serum levels of FGF-2, VEGF, HGF and PDGF-β were evaluated before and after radiotherapy by an enzyme-linked immunosorbent assay (ELISA). These levels were correlated both reciprocally and with age, histotype, stage and radiation dose.
After radiotherapy, FGF-2, VEGF and PDGF-β, but not HGF, significantly decreased in relation to the radiation dose and response. No correlation was established between cytokine levels, except for VEGF and PDGF-β, which decreased in parallel. Haemoglobin levels did not decrease after radiotherapy, while FGF-2, VEGF, HGF and PDGF-β levels did not correlate with age, NHL stage and histotype.
Soluble FGF-2, VEGF and PDGF-β levels decline after radiotherapy in NHLs, and may have predictive significance for response to treatment and recurrence.
KeywordsAngiogenesis Cytokines Non-Hodgkin lymphoma Prognosis Radiotherapy
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