Clinical and Experimental Medicine

, Volume 4, Issue 2, pp 78–85

Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation


DOI: 10.1007/s10238-004-0041-4

Cite this article as:
Porrata, L.F. & Markovic, S.N. Clin Exp Med (2004) 4: 78. doi:10.1007/s10238-004-0041-4


The anti-tumor activity of the immune system in the setting of hematopoietic stem cell transplantation has largely been described in the context of the “graft-versus-tumor” effect of allogeneic stem cell transplantation. This article reviews clinical evidence suggesting the existence of an autologous graft-versus-tumor effect in the setting of host immune system recovery following autologous stem cell transplantation resulting in prolongation of survival of cancer patients.

Key words

Absolute lymphocyte count Natural killer cells Autologous stem cell transplantation Kinetics Clinical outcome 

Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  1. 1.Division of Hematology, Department of Internal MedicineMayo ClinicRochesterUSA

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