Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation
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- Porrata, L.F. & Markovic, S.N. Clin Exp Med (2004) 4: 78. doi:10.1007/s10238-004-0041-4
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The anti-tumor activity of the immune system in the setting of hematopoietic stem cell transplantation has largely been described in the context of the “graft-versus-tumor” effect of allogeneic stem cell transplantation. This article reviews clinical evidence suggesting the existence of an autologous graft-versus-tumor effect in the setting of host immune system recovery following autologous stem cell transplantation resulting in prolongation of survival of cancer patients.