On the compressibility and poroelasticity of human and murine skin
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A total of 37 human and 33 murine skin samples were subjected to uniaxial monotonic, cyclic, and relaxation experiments. Detailed analysis of the three-dimensional kinematic response showed that skin volume is significantly reduced as a consequence of a tensile elongation. This behavior is most pronounced in monotonic but persists in cyclic tests. The dehydration associated with volume loss depends on the osmolarity of the environment, so that tension relaxation changes as a consequence of modifying the ionic strength of the environmental bath. Similar to ex vivo observations, complementary in vivo stretching experiments on human volar forearms showed strong in-plane lateral contraction. A biphasic homogenized model is proposed which allows representing all relevant features of the observed mechanical response.
KeywordsSkin biomechanics Mechanical characterization Compressibility Porous media Osmotic pressure
This work was conducted as part of the SKINTEGRITY flagship project of University Medicine Zurich and financially supported by the Swiss National Science Foundation (Grant No. 179012). We are grateful to the group of Prof. S. Werner (Institute of Molecular Health Sciences, ETH Zurich) for providing murine skins and to the group of Prof. E. Reichmann (Tissue Biology Research Unit, University Children’s Hospital Zurich) for use of their facilities in preparations for experiments on human skin.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Human and animal rights
All experiments involving human participants and human tissue were approved by the local ethical committees; details are given in Sect. 2.
Signed informed consent was provided from all participants and tissue donors.
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