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Biomechanics and Modeling in Mechanobiology

, Volume 16, Issue 5, pp 1697–1708 | Cite as

Capturing microscopic features of bone remodeling into a macroscopic model based on biological rationales of bone adaptation

  • Young Kwan Kim
  • Yoshitaka Kameo
  • Sakae Tanaka
  • Taiji Adachi
Original Paper

Abstract

To understand Wolff’s law, bone adaptation by remodeling at the cellular and tissue levels has been discussed extensively through experimental and simulation studies. For the clinical application of a bone remodeling simulation, it is significant to establish a macroscopic model that incorporates clarified microscopic mechanisms. In this study, we proposed novel macroscopic models based on the microscopic mechanism of osteocytic mechanosensing, in which the flow of fluid in the lacuno-canalicular porosity generated by fluid pressure gradients plays an important role, and theoretically evaluated the proposed models, taking biological rationales of bone adaptation into account. The proposed models were categorized into two groups according to whether the remodeling equilibrium state was defined globally or locally, i.e., the global or local uniformity models. Each remodeling stimulus in the proposed models was quantitatively evaluated through image-based finite element analyses of a swine cancellous bone, according to two introduced criteria associated with the trabecular volume and orientation at remodeling equilibrium based on biological rationales. The evaluation suggested that nonuniformity of the mean stress gradient in the local uniformity model, one of the proposed stimuli, has high validity. Furthermore, the adaptive potential of each stimulus was discussed based on spatial distribution of a remodeling stimulus on the trabecular surface. The theoretical consideration of a remodeling stimulus based on biological rationales of bone adaptation would contribute to the establishment of a clinically applicable and reliable simulation model of bone remodeling.

Keywords

Bone adaptation Wolff’s law Biological rationale Model reduction Multiscale biomechanics Mechanobiology 

Notes

Acknowledgements

This work was partially supported by the Advanced Research and Development Programs for Medical Innovation from the Japan Agency for Medical Research and Development (AMED-CREST).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Young Kwan Kim
    • 1
    • 2
  • Yoshitaka Kameo
    • 2
  • Sakae Tanaka
    • 1
  • Taiji Adachi
    • 2
  1. 1.Department of Orthopaedic Surgery, Faculty of MedicineThe University of TokyoTokyoJapan
  2. 2.Department of Biosystems Science, Institute for Frontier Life and Medical SciencesKyoto UniversityKyotoJapan

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