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Biomechanics and Modeling in Mechanobiology

, Volume 15, Issue 5, pp 1159–1172 | Cite as

Fluid mechanics of blood flow in human fetal left ventricles based on patient-specific 4D ultrasound scans

  • Chang Quan Lai
  • Guat Ling Lim
  • Muhammad Jamil
  • Citra Nurfarah  Zaini Mattar
  • Arijit Biswas
  • Choon Hwai YapEmail author
Original Paper

Abstract

The mechanics of intracardiac blood flow and the epigenetic influence it exerts over the heart function have been the subjects of intense research lately. Fetal intracardiac flows are especially useful for gaining insights into the development of congenital heart diseases, but have not received due attention thus far, most likely because of technical difficulties in collecting sufficient intracardiac flow data in a safe manner. Here, we circumvent such obstacles by employing 4D STIC ultrasound scans to quantify the fetal heart motion in three normal 20-week fetuses, subsequently performing 3D computational fluid dynamics simulations on the left ventricles based on these patient-specific heart movements. Analysis of the simulation results shows that there are significant differences between fetal and adult ventricular blood flows which arise because of dissimilar heart morphology, E/A ratio, diastolic–systolic duration ratio, and heart rate. The formations of ventricular vortex rings were observed for both E- and A-wave in the flow simulations. These vortices had sufficient momentum to last until the end of diastole and were responsible for generating significant wall shear stresses on the myocardial endothelium, as well as helicity in systolic outflow. Based on findings from previous studies, we hypothesized that these vortex-induced flow properties play an important role in sustaining the efficiency of diastolic filling, systolic pumping, and cardiovascular flow in normal fetal hearts.

Keywords

Cardiovascular Left ventricular fluid mechanics Human fetal Computational fluid dynamics simulations 

Notes

Acknowledgments

The authors would like to thank Singapore Ministry of Health, National Medical Research Council Grant Number NMRC/BNIG/2020/2014 (PI: Yap) for funding.

Supplementary material

Supplementary material 1 (mp4 2178 KB)

Supplementary material 2 (mp4 1820 KB)

Supplementary material 3 (mp4 1322 KB)

Supplementary material 4 (mp4 1043 KB)

Supplementary material 5 (mp4 1839 KB)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringNational University of SingaporeSingaporeSingapore
  2. 2.Department of Obstetrics and Gynecology, Yong Loo Lin School of MedicineNational University Health Systems, National University of SingaporeSingaporeSingapore

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