Biomechanics and Modeling in Mechanobiology

, Volume 15, Issue 5, pp 1079–1090 | Cite as

Multiscale modelling of solid tumour growth: the effect of collagen micromechanics

  • Peter A. Wijeratne
  • Vasileios Vavourakis
  • John H. Hipwell
  • Chrysovalantis Voutouri
  • Panagiotis Papageorgis
  • Triantafyllos Stylianopoulos
  • Andrew Evans
  • David J. Hawkes
Original Paper

Abstract

Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. We hypothesise that such a model, which provides a purely mechanical description of tumour–host interactions, can be used to explain experimental observations of the effect of collagen micromechanics on solid tumour growth. The model was specified to mouse tumour data, and numerical simulations were performed. The multiscale model produced lower stresses than an equivalent continuum-like approach, due to a more realistic remodelling of the collagen microstructure. Furthermore, solid tumour growth was found to cause a passive mechanical realignment of fibres at the tumour boundary from a random to a circumferential orientation. This is in accordance with experimental observations, thus demonstrating that such a response can be explained as purely mechanical. Finally, peritumoural fibre network anisotropy was found to produce anisotropic tumour morphology. The dependency of tumour morphology on the peritumoural microstructure was reduced by adding a load-bearing non-collagenous component to the fibre network constitutive equation.

Keywords

Tumour mechanics Microenvironment  Fibre remodelling Finite element analysis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Peter A. Wijeratne
    • 1
  • Vasileios Vavourakis
    • 1
  • John H. Hipwell
    • 1
  • Chrysovalantis Voutouri
    • 2
  • Panagiotis Papageorgis
    • 2
  • Triantafyllos Stylianopoulos
    • 2
  • Andrew Evans
    • 3
  • David J. Hawkes
    • 1
  1. 1.Department of Medical Physics and Bioengineering, Centre for Medical Image ComputingUniversity College London, Engineering Front Building, Malet PlaceLondonUK
  2. 2.Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing EngineeringUniversity of CyprusNicosiaCyprus
  3. 3.Ninewells Medical SchoolDundeeUK

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