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Biomechanics and Modeling in Mechanobiology

, Volume 13, Issue 6, pp 1199–1207 | Cite as

Compressive fatigue properties of a commercially available acrylic bone cement for vertebroplasty

  • Ingrid Ajaxon
  • Cecilia PerssonEmail author
Original Paper

Abstract

Acrylic bone cements are widely used for fixation of joint prostheses as well as for vertebral body augmentation procedures of vertebroplasty and balloon kyphoplasty, with the cement zone(s) being subjected to repeated mechanical loading in each of these applications. Although, in vertebroplasty and balloon kyphoplasty, the cement zone is exposed to mainly cyclical compressive load, the compressive fatigue properties of acrylic bone cements used in these procedures are yet to be determined. The purposes of the present study were to determine the compressive fatigue properties of a commercially available cement brand used in vertebroplasty, including the effect of frequency on these properties; to identify the cement failure modes under compressive cyclical load; and to introduce a screening method that may be used to shorten the lengthy character of the standardized fatigue tests. Osteopal\({^\circledR } \mathrm{V}\) was used as the model cement in this study. The combinations of maximum stress and frequency used were 50.0, 55.0, 60.0, 62.5 and 75.5 MPa at 2 Hz; and of 40.0, 55.0, 60.0, 62.5 or 75.5 MPa at 10 Hz. Through analysis of nominal strain-number of loading cycles results, three cement failure modes were identified. The estimated mean fatigue limit at 2 Hz (55.4 MPa) was significantly higher than that at 10 Hz (41.1 MPa). The estimated fatigue limit at 2 Hz is much higher than stresses commonly found in the spine and also higher than that for other acrylic bone cements tested in a full tension–compression fatigue test, which indicates that tension–compression fatigue testing may substantially underestimate the performance of cements intended for vertebroplasty. A screening method was introduced which may be used to shorten the time spent in performing compressive fatigue tests on specimens of acrylic bone cement for use in vertebral body augmentation procedures.

Keywords

Acrylic bone cement Vertebroplasty Compressive fatigue properties 

Notes

Acknowledgments

Funding from the Swedish research council (621-2011-6258), Vinnova (VINNMER 2010-02073) and the European Union (FP7-PEOPLE-2010-268134) is gratefully acknowledged. The authors extend their appreciation to Dr. Anders Persson, Department of Physics and Astronomy, Uppsala University, for his assistance with MATLAB.

References

  1. ASTM (2009) ASTM F2118-03: Standard test method for constant amplitude of force controlled fatigue testing of acrylic bone cement materialsGoogle Scholar
  2. ASTM (2008) ASTM F 451-08: Standard specification for acrylic bone cementGoogle Scholar
  3. Augat P, Link T, Lang TF et al (1998) Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations. Med Eng Phys 20:124–131CrossRefGoogle Scholar
  4. Boelen EJH, Lewis G, Xu J et al (2008) Evaluation of a highly-radiopaque iodine-containing acrylic bone cement for use in augmentation of vertebral compression fractures. J Biomed Mater Res A 86A:76–88. doi: 10.1002/jbm.a.31601 CrossRefGoogle Scholar
  5. Charnley J (1960) Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg Br 42-B:28–30Google Scholar
  6. Cristofolini L, Minari C, Viceconti M (2000) A methodology and criterion for acrylic bone cement fatigue tests. Fatigue Fract Eng Mater Struct 23:953–957CrossRefGoogle Scholar
  7. Follet H, Viguet-Carrin S, Burt-Pichat B et al (2010) Effects of preexisting microdamage, collagen cross-links, degree of mineralization, age, and architecture on compressive mechanical properties of elderly human vertebral trabecular bone. J Orthop Res 29:481–488. doi: 10.1002/jor.21275 CrossRefGoogle Scholar
  8. Freitag TA, Cannon (1977) Fracture characteristics of acrylic bone cements. II. Fatigue. J Biomed Mater Res B 11:609–624Google Scholar
  9. Galibert P, Deramond H, Rosat P, Le Gars D (1987) Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 33:166–168Google Scholar
  10. Gates EI, Carter DR, Harris WH (1983) Tensile fatigue failure of acrylic bone cement. J Biomech Eng 105:393–397CrossRefGoogle Scholar
  11. ISO (2008) ISO 16402. 1–12Google Scholar
  12. Johnson JA, Provan JW, Krygier JJ et al (1989) Fatigue of acrylic bone cement—effect of frequency and environment. J Biomed Mater Res B 23:819–831CrossRefGoogle Scholar
  13. Kaiser T (1989) Highly crosslinked polymers. Prog Polym Sci 14:373–450CrossRefGoogle Scholar
  14. Keller TS (1994) Predicting the compressive mechanical behavior of bone. J Biomech 27:1159–1168CrossRefGoogle Scholar
  15. Köster U, Jaeger R, Bardts M et al (2013) Creep and fatigue behavior of a novel 2-component paste-like formulation of acrylic bone cements. J Mater Sci: Mater Med 24:1395–1406. doi: 10.1007/s10856-013-4909-2 Google Scholar
  16. Krause WR, Grimes LW, Mathis RS (1988) Fatigue testing of acrylic bone cements: statistical concepts and proposed test methodology. J Biomed Mater Res-A 22:179–190CrossRefGoogle Scholar
  17. Kurtz SM, Villarraga ML, Zhao K, Edidin AA (2005) Static and fatigue mechanical behavior of bone cement with elevated barium sulfate content for treatment of vertebral compression fractures. Biomaterials 26:3699–3712. doi: 10.1016/j.biomaterials.2004.09.055 Google Scholar
  18. Lewis G (2000) Relative roles of cement molecular weight and mixing method on the fatigue performance of acrylic bone cement: Simplex P versus Osteopal. J Biomed Mater Res-A 53:119–130CrossRefGoogle Scholar
  19. Lewis G (2003) Fatigue testing and performance of acrylic bone-cement materials: State-of-the-art review. J Biomed Mater Res B 66:457–486. doi: 10.1002/jbm.b.10018
  20. Lewis G (2006) Injectable bone cements for use in vertebroplasty and kyphoplasty: State-of-the-art review. J Biomed Mater Res B 76B:456–468. doi: 10.1002/jbm.b.30398
  21. Lewis G (2011) Viscoelastic properties of injectable bone cements for orthopaedic applications: State-of-the-art review. J Biomed Mater Res B 98B:171–191. doi: 10.1002/jbm.b.31835
  22. Lewis G, Austin GE (1994) Mechanical properties of vacuum-mixed acrylic bone cement. J Appl Biomater 5:307–314. doi: 10.1002/jab.770050405 CrossRefGoogle Scholar
  23. Lewis G, Janna S, Carroll M (2003) Effect of test frequency on the in vitro fatigue life of acrylic bone cement. Biomaterials 24:1111–1117CrossRefGoogle Scholar
  24. Lewis G, Koole LH, van Hooy-Corstjens CSJ (2009a) Influence of powder-to-liquid monomer ratio on properties of an injectable iodine-containing acrylic bone cement for vertebroplasty and balloon kyphoplasty. J Biomed Mater Res B 91B:537–544. doi: 10.1002/jbm.b.31427 CrossRefGoogle Scholar
  25. Lewis G, Mladsi S (1998) Effect of sterilization method on properties of Palacos R acrylic bone cement. Biomaterials 19:117–124CrossRefGoogle Scholar
  26. Lewis G, Schwardt JD, Slater TA, Janna S (2008) Evaluation of a synthetic vertebral body augmentation model for rapid and reliable cyclic compression life testing of materials for balloon kyphoplasty. J Biomed Mater Res B 87B:179–188. doi: 10.1002/jbm.b.31089 CrossRefGoogle Scholar
  27. Lewis G, Towler MR, Boyd D et al (2009b) Evaluation of two novel aluminum-free, zinc-based glass polyalkenoate cements as alternatives to PMMA bone cement for use in vertebroplasty and balloon kyphoplasty. J Mater Sci: Mater Med 21:59–66. doi: 10.1007/s10856-009-3845-7 Google Scholar
  28. Little RE (1975) STP588 Manual on statistical planning and analysis. ASTM InternationalGoogle Scholar
  29. Nazarian A, Stechow D, Zurakowski D et al (2008) Bone volume fraction explains the variation in strength and stiffness of cancellous bone affected by metastatic cancer and osteoporosis. Calcif Tissue Int 83:368–379. doi: 10.1007/s00223-008-9174-x CrossRefGoogle Scholar
  30. Rittel D (2000) An investigation of the heat generated during cyclic loading of two glassy polymers. Part I: Experimental. Mech Mater 32:131–147Google Scholar
  31. Rubiolo GH, Muar RH (1996) Effects of fatigue damage on the compression yield stress of PMMA at 298 K. An Asoc Quim Argent 84:95–99Google Scholar
  32. Schwartz EN, Steinberg D (2005) Detection of vertebral fractures. Curr Osteoporos Rep 3:126–135CrossRefGoogle Scholar
  33. Serbetci K, Korkusuz F, Hasirci N (2004) Thermal and mechanical properties of hydroxyapatite impregnated acrylic bone cements. Polym Test 23:145–155. doi: 10.1016/S0142-9418(03)00073-4 CrossRefGoogle Scholar
  34. Vallo CI, Montemartini PE, Cuadrado TR (1998) Effect of residual monomer content on some properties of a poly (methyl methacrylate)-based bone cement. J Appl Polym Sci 69:1367–1383CrossRefGoogle Scholar
  35. Verdonschot N, Huiskes R (1995) Dynamic creep behavior of acrylic bone cement. J Biomed Mater Res 29:575–581CrossRefGoogle Scholar
  36. Wilke HJ, Neef P, Caimi M et al (1999) New in vivo measurements of pressures in the intervertebral disc in daily life. Spine 24:755CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Applied Materials Science, Department of Engineering SciencesUppsala UniversityUppsalaSweden

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