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Biomechanics and Modeling in Mechanobiology

, Volume 13, Issue 2, pp 239–258 | Cite as

Multiscale modeling of blood flow: from single cells to blood rheology

  • Dmitry A. Fedosov
  • Hiroshi Noguchi
  • Gerhard Gompper
Original Paper

Abstract

Mesoscale simulations of blood flow, where the red blood cells are described as deformable closed shells with a membrane characterized by bending rigidity and stretching elasticity, have made much progress in recent years to predict the flow behavior of blood cells and other components in various flows. To numerically investigate blood flow and blood-related processes in complex geometries, a highly efficient simulation technique for the plasma and solutes is essential. In this review, we focus on the behavior of single and several cells in shear and microcapillary flows, the shear-thinning behavior of blood and its relation to the blood cell structure and interactions, margination of white blood cells and platelets, and modeling hematologic diseases and disorders. Comparisons of the simulation predictions with existing experimental results are made whenever possible, and generally very satisfactory agreement is obtained.

Keywords

Red blood cell Dissipative particle dynamics Multiparticle collision dynamics Blood rheology  Shear-thinning Capillary flow Microvessels  Discocyte, parachute, and slipper shapes 

Abbreviations

MD

Molecular dynamics

DPD

Dissipative particle dynamics

MPC

Multiparticle collision dynamics

SPH

Smoothed particle hydrodynamics

BD

Brownian dynamics

LBM

Lattice Boltzmann method

CFD

Computational fluid dynamics

IBM

Immersed boundary method

FTM

Front tracking method

RBC

Red blood cell

WBC

White blood cell

GUV

Giant unilamellar vesicle

KS

Keller–Skalak theory

RDF

Radial distribution function

CFL

Cell-free layer

Pf

Plasmodium falciparum

ATP

Adenosine triphosphate

2D

Two dimensions

3D

Three dimensions

Notes

Acknowledgments

We would like to acknowledge support by the German Science Foundation (DFG) through the research unit FOR 1543, “Shear flow regulation of hemostasis—bridging the gap between nanomechanics and clinical presentation (SHENC)”. We thank the Jülich Supercomputing Centre (JSC) at the Forschungszentrum Jülich for providing computer resources. D.A.F. acknowledges funding by the Alexander von Humboldt Foundation.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Dmitry A. Fedosov
    • 1
  • Hiroshi Noguchi
    • 2
  • Gerhard Gompper
    • 1
  1. 1.Theoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced SimulationForschungszentrum JülichJülichGermany
  2. 2.Institute for Solid State PhysicsUniversity of TokyoChibaJapan

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