Potential fluid mechanic pathways of platelet activation
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Platelet activation is a precursor for blood clotting, which plays leading roles in many vascular complications and causes of death. Platelets can be activated by chemical or mechanical stimuli. Mechanically, platelet activation has been shown to be a function of elevated shear stress and exposure time. These contributions can be combined by considering the cumulative stress or strain on a platelet as it is transported. Here, we develop a framework for computing a hemodynamic-based activation potential that is derived from a Lagrangian integral of strain rate magnitude. We demonstrate that such a measure is generally maximized along, and near to, distinguished material surfaces in the flow. The connections between activation potential and these structures are illustrated through stenotic flow computations. We uncover two distinct structures that may explain observed thrombus formation at the apex and downstream of stenoses. More broadly, these findings suggest fundamental relationships may exist between potential fluid mechanic pathways for mechanical platelet activation and the mechanisms governing their transport.
KeywordsClotting Hemodynamics Lagrangian coherent structures Stenosis Thrombosis Transport
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- Boreda R, Fatemi RS, Rittgers SE (1995) Potential for platelet stimulation in critically stenosed carotid and coronary arteries. J Vasc Invest 1(1): 26–37Google Scholar
- Cho YI, Kensey R (1991) Effects of the non-Newtonian viscosity of blood flows in a diseased arterial vessel part 1: steady flows. Biorheology 28: 241–262Google Scholar
- Cokelet GR (1972) The rheology of human blood. In: Fung YC, Perrone N, Anliker M (eds) Biomechanics: its foundations and objectives. Prentice-Hall, Englewood Cliffs, pp 63–103Google Scholar
- LaDisa JF, Hettrick DA, Olson LE, Guler I, Gross ER, Kress TT, Kersten JR, Warltier DC, Pagel PS (2002) Stent implantation alters coronary artery hemodynamics and wall shear stress during maximal vasodilation. J Appl Phys 93(6): 1939–1946Google Scholar
- Purvis NB, Giorgio TD (1991) The effect of elongational stress exposure on the activation and aggregation of blood-platelets. Biorheology 28(5): 355–367Google Scholar
- Shadden SC (2011) Lagrangian coherent structures. In: Grigoriev R (ed) Transport and Mixing in Laminar Flows: From Microfluidics to Oceanic Currents. Wiley-VCH Verlag GmbH & Co. KGaA, New York, pp 59–89Google Scholar