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Biomechanics and Modeling in Mechanobiology

, Volume 10, Issue 2, pp 269–279 | Cite as

Contribution of postnatal collagen reorientation to depth-dependent mechanical properties of articular cartilage

  • Mark C. van TurnhoutEmail author
  • Sander Kranenbarg
  • Johan L. van Leeuwen
Open Access
Short Communication

Abstract

The collagen fibril network is an important factor for the depth-dependent mechanical behaviour of adult articular cartilage (AC). Recent studies show that collagen orientation is parallel to the articular surface throughout the tissue depth in perinatal animals, and that the collagen orientations transform to a depth-dependent arcade-like structure in adult animals. Current understanding on the mechanobiology of postnatal AC development is incomplete. In the current paper, we investigate the contribution of collagen fibril orientation changes to the depth-dependent mechanical properties of AC. We use a composition-based finite element model to simulate in a 1-D confined compression geometry the effects of ten different collagen orientation patterns that were measured in developing sheep. In initial postnatal life, AC is mostly subject to growth and we observe only small changes in depth-dependent mechanical behaviour. Functional adaptation of depth-dependent mechanical behaviour of AC takes place in the second half of life before puberty. Changes in fibril orientation alone increase cartilage stiffness during development through the modulation of swelling strains and osmotic pressures. Changes in stiffness are most pronounced for small stresses and for cartilage adjacent to the bone. We hypothesize that postnatal changes in collagen fibril orientation induce mechanical effects that in turn promote these changes. We further hypothesize that a part of the depth-dependent postnatal increase in collagen content in literature is initiated by the depth-dependent postnatal increase in fibril strain due to collagen fibril reorientation.

Keywords

Articular cartilage Collagen network Development Depth-dependent properties Fibril reinforced poroviscoelastic swelling model 

Notes

Acknowledgments

The authors are grateful to Dr.Wouter Wilson and Dr. René van Donkelaar at the Materials Technology group of the Faculty of Biomedical Engineering of Eindhoven University of Technology for the use of, and support with, the FRPVS model.

Open Access

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Copyright information

© The Author(s) 2010

Authors and Affiliations

  • Mark C. van Turnhout
    • 1
    Email author
  • Sander Kranenbarg
    • 1
  • Johan L. van Leeuwen
    • 1
  1. 1.Experimental Zoology Group, Department of Animal SciencesWageningen UniversityWageningenThe Netherlands

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