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Biomechanics and Modeling in Mechanobiology

, Volume 6, Issue 5, pp 321–331 | Cite as

Computational modeling of arterial wall growth

Attempts towards patient-specific simulations based on computer tomography
  • E. Kuhl
  • R. Maas
  • G. Himpel
  • A. Menzel
Original Paper

Abstract

The present manuscript documents our first experiences with a computational model for stress- induced arterial wall growth and in-stent restenosis related to atherosclerosis. The underlying theoretical framework is provided by the kinematics of finite growth combined with open system thermodynamics. The computational simulation is embedded in a finite element approach in which growth is essentially captured by a single scalar-valued growth factor introduced as internal variable on the integration point level. The conceptual simplicity of the model enables its straightforward implementation into standard commercial finite element codes. Qualitative studies of stress-induced changes of the arterial wall thickness in response to balloon angioplasty or stenting are presented to illustrate the features of the suggested growth model. First attempts towards a patient-specific simulation based on realistic artery morphologies generated from computer tomography data are discussed.

Keywords

Finite growth Open system thermodynamics Stress-induced growth Restenosis Patient specific simulation 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Chair of Applied Mechanics, Department of Mechanical and Process EngineeringUniversity of KaiserslauternKaiserslauternGermany

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