Journal of Cutaneous Medicine and Surgery

, Volume 8, Issue 4, pp 205–212 | Cite as

Understanding the New Clinical Landscape for Psoriasis: A Comparative Review of Biologics

Basic/Clinical Science

Abstract

Background

Encouraging results from clinical trials suggest that biologic therapies are effective treatments for psoriasis.

Objective

The aim of our study was to evaluate the scientific evidence for the efficacy and safety of biologic drugs for psoriasis.

Methods

The studies reviewed include data on the biologies alefacept, efalizumab, etanercept, and infliximab. This article reviews all data published in the dermatology literature listed in the MEDLINE database, as well as data presented as abstracts and posters at dermatology society meetings, including the annual meetings of the American Academy of Dermatology.

Results

The majority of the studies used an improvement from baseline of 75% or more in the psoriasis area and severity index (PASI 75) as the primary measure of efficacy.

Conclusions

Overall, biologics represent an important addition to the psoriatic therapies and have a great impact on the disease course and life quality of those afflicted with psoriasis.

Sommaire

Antécédents

Des résultats encourageants d’essais cliniques indiquent que les biothérapies sont efficaces dans le traitement du psoriasis.

Objectif

Évaluer les preuves scientifiques montant l’innocuité et l’efficacité des medicaments biologiques dans le traitement du psoriasis.

Méthodes

Les études examinées comprennent des données sur les médicaments biologiques alefacept, efalizumab, etanercept et infliximab. Le présent article passe en revue l’ensemble des données publiées dans les périodiques spécialisés en dermatologie et listés sur la base MEDLINE, ainsi que les données présentées dans les résumés et sur les affiches des congrès de sociétés de dermatologues, notamment la réunion annuelle de la American Academy of Dermatology.

Résultats

La majorité des études ont utilisé comme principale mesure d’efficacité une amélioration de 75 % de l’indice de surface et de sévérité du psoriasis (PASI 75).

Conclusion

En général, la biothérapie représente un ajout important au traitement du psoriasis; elle a une grande incidence sur le cours de la maladie et la qualité de vie de ceux qui en sont atteints.

Notes

Acknowledgments

Dr. Mamelak was funded by a grant from Connetics.

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Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  1. 1.Department of DermatologyThe Johns Hopkins University School of MedicineBaltimoreUSA

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