The European Journal of Health Economics

, Volume 13, Issue 4, pp 501–510 | Cite as

A proposed model for economic evaluations of major depressive disorder

  • Hossein Haji Ali AfzaliEmail author
  • Jonathan Karnon
  • Jodi Gray
Original Paper


In countries like UK and Australia, the comparability of model-based analyses is an essential aspect of reimbursement decisions for new pharmaceuticals, medical services and technologies. Within disease areas, the use of models with alternative structures, type of modelling techniques and/or data sources for common parameters reduces the comparability of evaluations of alternative technologies for the same condition. The aim of this paper is to propose a decision analytic model to evaluate long-term costs and benefits of alternative management options in patients with depression. The structure of the proposed model is based on the natural history of depression and includes clinical events that are important from both clinical and economic perspectives. Considering its greater flexibility with respect to handling time, discrete event simulation (DES) is an appropriate simulation platform for modelling studies of depression. We argue that the proposed model can be used as a reference model in model-based studies of depression improving the quality and comparability of studies.


Economic evaluation Decision modelling Depression Discrete event simulation 

JEL Classification

I18 I19 



This study would not have been possible without the financial support of the Australian Research Council and the South Australia Department of Health. We also thank Justin Beilby, Chris Holton, Adam Elshaug, Barbara Magin, David Banham, Michelle Noort, Wendy Sutton, Adair Garrett for their recommendations.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Hossein Haji Ali Afzali
    • 1
    Email author
  • Jonathan Karnon
    • 1
  • Jodi Gray
    • 1
  1. 1.Discipline of Public HealthThe University of AdelaideAdelaideAustralia

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