The Journal of Headache and Pain

, Volume 3, Issue 1, pp 51–53 | Cite as

A case of MELAS syndrome with typical cluster headache attacks: is it a causel or coincidental association?

  • Brune M. FuscoEmail author
  • Mario Giacovazzo
Open Access
Brief Report


Many findings relate migraine and cluster headaches to a genetic alteration, even if the site of the defect has not been identified. Some of these findings indicate an involvement of mitochondrial DNA, although some contrasting results have been reported. We describe a case of cluster headache occuring in a patient with MELAS syndrome. The diagnosis of MELAS was supported by the familiar anamnesis (the mother suffered from a similar form), by the laboratory reports (lacto-acidosis), by instrumental analysis (signs of encephalopathy on magnetic resonance imaging) and by biopsy findings (myopathy). The diagnosis was confirmed when a point mutation (Leu mutation at position 3423 of mitochondrial RNA) was found in the mitochondrial gene. The recurrent periods, characterized by attacks of unilateral pain and accompanied by homolateral symptoms (e. g. tearing, palpebral ptosis, rhinorrea), did not leave any doubt as to the diagnosis of cluster headache. We discuss whether the co-existence of MELAS and cluster headache was coincidental or causal.

Key words

Cluster headache mtDNA Lacto-acidosis MELAS Mitochondrial disease 

Copyright information

© Springer-Verlag Italia 2002

Authors and Affiliations

  1. 1.Department of Pharmaceutical ScienceUnivesity of SalermoFsciano (SA)Italy
  2. 2.Institute of Internal Medicine, Second Faculty of MedicineLa Sapienza University of RomeRomeItaly

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