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The Journal of Headache and Pain

, Volume 1, Supplement 2, pp S177–S181 | Cite as

The genetic regulation of SCN in cluster headache may be affected by Th1/Th2 cytokine derangement

  • Alessandra Zicari
  • Giuseppe Stirparo
  • Cristina Rinaldi
  • Mario Giacovazzo
  • Stefania Morrone
  • Paolo Martelletti
  • 143 Downloads

Abstract

T lymphocytes participate not only in immune responses but also in the development of several pathologic reactions. Human T helper cells, on the basis of the cytokines they release, fall into two phenotypes, namely TH1 and TH2. The aim of the present research was to assess whether T lymphocytes are involved in cluster headache pathogenesis. We studied 12 cluster headache patients and 6 control cases in terms of T lymphocyte subsets and their related cytokine release. Our results show that during a cluster headache attack, the TH1 subset is activated, whereas in the periods between and out of the crisis, the TH2 cells become predominant. The possible role played by T lymphocytes and cytokines in the biomolecular phenomenon leading to cluster headache is discussed.

Key words T lymphocytes Cytokines Cluster headache Genetic clock regulation 

Copyright information

© Springer-Verlag Italia 2000

Authors and Affiliations

  • Alessandra Zicari
    • 1
  • Giuseppe Stirparo
    • 2
  • Cristina Rinaldi
    • 1
  • Mario Giacovazzo
    • 3
  • Stefania Morrone
    • 1
  • Paolo Martelletti
    • 3
  1. 1.Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Rome, ItalyIT
  2. 2.CNR, Institute of Biomedical Technologies, University of Rome La Sapienza, Rome, ItalyIT
  3. 3.Internal Medicine Institute, Headache Center, Sant'Andrea Hospital, Via die Grottarossa 1035-9, I-00189 Rome, Italy, e-mail: paolo.martelletti@uniroma1.it, Tel.: +39-06-4453983, Fax: +39-06-49388805IT

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