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The Journal of Headache and Pain

, Volume 1, Supplement 2, pp S165–S167 | Cite as

A study of Italian families with cluster headache

  • Massimo Leone
  • Michael Bjørn Russell
  • Andrea Rigamonti
  • Angelo Attanasio
  • Licia Grazzi
  • Domenico D'Amico
  • Susanna Usai
  • Gennaro Bussone
  • 119 Downloads

Abstract

A Danish genetic study showed increased risk of cluster headache (CH) among relatives of CH patients. We studied the families of 191 CH patients (118 males, 73 females; mean age 45.9 years) attending the Milan Headache Center. Information on 3589 relatives was collected by direct interview of the probands (n = 118) or by mailed questionnaire (n = 73). The diagnostic criteria of the IHS were used. A positive family history was found in 19% (37 of 191) of the families. A total of 32 first-degree (32 of 1036, 3.1%) and 15 second-degree (15 of 2553, 0.6%) relatives were affected. The relative risk of CH was 26.89 (95% CI, 17.57–36.21) in the first-degree relatives and 4.35 (95% CI, 2.13–5.21) in second-degree relatives. This study shows increased familial risk of cluster headache in an Italian population and confirms that cluster headache is, in some families, and inherited disorder.

Key words Cluster headache Familial occurrence Genetics 

Copyright information

© Springer-Verlag Italia 2000

Authors and Affiliations

  • Massimo Leone
    • 1
  • Michael Bjørn Russell
    • 2
  • Andrea Rigamonti
    • 1
  • Angelo Attanasio
    • 1
  • Licia Grazzi
    • 1
  • Domenico D'Amico
    • 1
  • Susanna Usai
    • 1
  • Gennaro Bussone
    • 1
  1. 1.Carlo Besta National Neurological Institute, Via Celoria 11, I-20133 Milan, Italy, e-mail: leone@istituto-besta.it, Tel.: +39-02-2394264, Fax: +39-02-70638067IT
  2. 2.Department of Neurology, Copenhagen University Hospital, University of Copenhagen, Copenhagen, DenmarkDK

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