The Journal of Headache and Pain

, Volume 8, Issue 5, pp 277–282 | Cite as

Cluster headache and intracranial aneurysm

  • Marcelo Moraes ValençaEmail author
  • Luciana P. A. Andrade-Valença
  • Carolina Martins
  • Maria Fátima Vasco de Aragão
  • Laécio Leitão Batista
  • Mario Fernando Prieto Peres
  • Wilson Farias da Silva
Open Access


In the present study we describe the cases of two patients with cluster-like headache related to intracranial carotid artery aneurysm. One of these patients responded to verapamil prescription with headache resolution. In both cases the surgical clipping of the aneurysm resolved the cluster pain. These findings strongly suggest a pathophysiological link between the two conditions. The authors discuss the potential pathophysiological mechanisms underlying cluster-like headache due to intracranial carotid artery aneurysm.


Cerebral aneurysm Cluster headache Parasympathetic Third cranial nerve Internal carotid artery Pathophysiology 


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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Marcelo Moraes Valença
    • 1
    Email author
  • Luciana P. A. Andrade-Valença
    • 2
  • Carolina Martins
    • 1
  • Maria Fátima Vasco de Aragão
    • 1
  • Laécio Leitão Batista
    • 1
  • Mario Fernando Prieto Peres
    • 3
  • Wilson Farias da Silva
    • 1
  1. 1.Division of Neurology and Neurosurgery, Department of NeuropsychiatryFederal University of PernambucoRecife, PernambucoBrazil
  2. 2.Service of NeurologyUniversity of PernambucoRecifeBrazil
  3. 3.Hospital Israelita Albert EinsteinSão PauloBrazil

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