The Journal of Headache and Pain

, Volume 5, Supplement 2, pp s74–s77 | Cite as

The effect of placebo and neurophysiological involvements

  • Federica Galli
  • Barbara Riccio
  • Vincenzo GuidettiEmail author


Placebo and placebo effect are important issues related to the drug therapy for clinical and scientific meanings. The rates of placebo may get as many as 50% for analgesic drugs in headache. The high answer to placebo brings questions on pathophysiology of headache. Answers may offer a new strategy in the implementation of trials and new insight in neurophysiology of headache. Current knowledge on placebo and placebo effect will be analysed and dicussed looking for new direction in headache field.

Key words

Placebo Headache Migraine Treatment Drug therapy 

Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  • Federica Galli
    • 1
  • Barbara Riccio
    • 1
  • Vincenzo Guidetti
    • 1
    Email author
  1. 1.Interuniversity Center for the Study of the Headache and Neurotrasmitter Disorders University of Bari, Napoli, Perugia, Roma, Sassari, Section of Rome,Childhood and Adolescence Headache Center, Department of Child and Adolescent Neurology and Psychiatry University “La Sapienza”RomeItaly

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