Assessment of the Birmingham vasculitis activity score in patients with MPO-ANCA-associated vasculitis: sub-analysis from a study by the Japanese Study Group for MPO-ANCA-associated vasculitis

  • Wako Yumura
  • Shigeto Kobayashi
  • Machi Suka
  • Taichi Hayashi
  • Satoshi Ito
  • Hiroko Nagafuchi
  • Hidehiro Yamada
  • Shoichi Ozaki
Original Article

DOI: 10.1007/s10165-013-0889-9

Cite this article as:
Yumura, W., Kobayashi, S., Suka, M. et al. Mod Rheumatol (2013). doi:10.1007/s10165-013-0889-9

Abstract

Objectives

In the study cohort enrolled in a prospective open-label, multicenter trial conducted by the Japanese Study Group for MPO-ANCA-associated vasculitis (JMAAV), we conducted this sub-analysis to establish the validity of the Birminghan vasculitis activity score (BVAS) for Japanese patients with MPO-ANCA-associated vasculitis.

Methods

We recorded the BVAS at the time of diagnosis, at 6 weeks after the diagnosis, and at 3, 6, 9, 12, 15 and 18 months after the diagnosis in this study.

Results

The most frequently involved organs in the patients were the lungs, kidneys and the nervous system. The kidney (BVAS; new/worse 69.2 %, persistent 40.4 %), general (BVAS; new/worse 67.3 %, persistent 53.8 %), chest (BVAS; new/worse 36.5 %, persistent 46.2 %) and nervous system (BVAS; new/worse 38.5 %, persistent 25.0 %) were the organ systems most frequently involved by the disease at the baseline. The BVAS for new/worse disease decreased immediately after induction therapy, while improvement of the BVAS for persistent disease after therapy differed among the organ systems.

Conclusions

BVAS was demonstrated to be a valuable guide for selection of the optimal treatment. Thus, BVAS was also found to be a useful tool in Japanese patients for the assessment of disease activity and degree of organ damage in patients with MPO-ANCA-associated vasculitis.

Keywords

MPO-ANCA associated vasculitis Microscopic polyangiitis BVAS (Birmingham vasculitis activity score) Rapidly progressive glomerulonephritis Interstitial pneumonia 

Copyright information

© Japan College of Rheumatology 2013

Authors and Affiliations

  • Wako Yumura
    • 6
  • Shigeto Kobayashi
    • 1
  • Machi Suka
    • 2
  • Taichi Hayashi
    • 3
  • Satoshi Ito
    • 4
  • Hiroko Nagafuchi
    • 5
  • Hidehiro Yamada
    • 5
  • Shoichi Ozaki
    • 5
  1. 1.Division of Internal MedicineJuntendo UniversityKoshigayaJapan
  2. 2.Department of Public Health and Environmental MedicineThe Jikei University School of MedicineTokyoJapan
  3. 3.Division of Internal Medicine, Faculty of MedicineUniversity of TsukubaTsukubaJapan
  4. 4.Division of RheumatologyNiigata Rheumatic CenterNiigataJapan
  5. 5.Division of Rheumatology and Allergology, Department of Internal MedicineSt. Marianna University School of MedicineKawasakiJapan
  6. 6.Department of Nephrology, Internal MedicineInternational University of Health and Warfare HospitalNasushiobaraJapan

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