Clinical results of alendronate monotherapy and combined therapy with menatetrenone (VitK2) in postmenopausal RA patients
We aimed to evaluate the clinical efficacy of monotherapy with alendronate and combined therapy with alendronate and menatetrenone (vitamin K2 [VitK2]) in postmenopausal rheumatoid arthritis (RA) patients with osteoporosis or osteopenia.
Sixty-two postmenopausal RA patients with untreated osteoporosis or osteopenia (lumbar spine bone density ≤80 % of young adult mean [YAM]) were enrolled: 39 had abnormal serum undercarboxylated osteocalcin (ucOC) levels (>4.5 ng/mL) and received combined therapy with alendronate (35 mg/week) and VitK2 (45 mg/day) (ALN + K group); 23 had normal ucOC levels (≤4.5 ng/mL) and received alendronate monotherapy (35 mg/week) (ALN group). The clinical results for the 57 patients in both groups were evaluated after 1-year treatment.
The mean baseline/follow-up (FU) lumbar spine bone density (%YAM) values were 73.0/76.8 % (P < 0.01) in the ALN + K group and 77.0/80.3 % (P < 0.01) in the ALN group; a significant increase was shown in both groups. Mean proximal femoral bone density values at baseline/FU were 71.4/73.8 (P < 0.01) in the ALN + K group and 71.4/71.6 % (not significant; NS) in the ALN group; a significant increase was shown in the ALN + K group only. Serum ucOC levels were normalized in the ALN + K group at FU. At FU, bone metabolism markers [bone-specific alkaline phosphatase (BAP) and N-terminal cross-linked telopeptides of type I collagen] were decreased in both groups. One patient in the ALN + K group and three in the ALN group suffered new fractures.
Combined therapy with alendronate and VitK2 decreases bone metabolism marker levels and serum ucOC levels, and increases lumbar spine and femoral neck bone density in postmenopausal RA patients with abnormal ucOC levels and osteoporosis or osteopenia.
KeywordsUndercarboxylated osteocalcin (ucOC) Rheumatoid arthritis (RA) Menatetrenone (VitK2) Alendronate (ALN) Osteoporosis
- 3.No authors listed. Osteoporosis prevention, diagnosis, and therapy. NIH Consens Statement. 2000;17:1–45.Google Scholar
- 10.Kai M, Makino S, Yuasa M, Nishijima T. Study of bone vitamin K deficiency of RA patients-Evaluation with the measurement of ucOC in serum. Rheumatology.2009;42:133–8 (in Japanese).Google Scholar
- 12.Nakayama H, Hagiwara F, Tohma S. Three-year effects of bisphosphonates on treatment of osteoporosis and on reducing the risk for vertebral fractures of rheumatoid arthritis patients. Osteoporos Japan. 2007;15:13–8.Google Scholar