Advertisement

Modern Rheumatology

, Volume 20, Issue 4, pp 396–400 | Cite as

Multiple dermatofibromas in a patient with systemic lupus erythematosus and Sjögren’s syndrome

  • Tomomi Fujisawa
  • Mariko SeishimaEmail author
Case Report

Abstract

We report a case of multiple dermatofibromas in a patient with systemic lupus erythematosus (SLE) and Sjögren’s syndrome. He was treated with prednisolone, diaphenylsulfone, and cyclosporine for SLE. He noticed two brown nodules on his right lower leg 3 years after the first consultation. Subsequently, six nodules developed within 6 months, and 2 more nodules after 10 months. Histopathological examination of a nodule on his left hand showed fibrotic proliferation with a storiform pattern in the whole dermis, but neither necrosis nor mitosis was observed. From these findings, a diagnosis of multiple dermatofibromas was made. As these tumors appeared during the remission stage of SLE, they might have been under immunosuppressive conditions caused by immunosuppressing agents rather than collagen disease itself.

Keywords

Multiple dermatofibromas Systemic lupus erythematosus Sjögren’s syndrome Corticosteroids Cyclosporine 

Notes

Conflict of interest statement

None.

References

  1. 1.
    Baraf CS, Shapiro L. Multiple histiocytomas. Arch Dermatol. 1970;101:588–90.CrossRefPubMedGoogle Scholar
  2. 2.
    Newman DM, Walter JB. Multiple dermatofibromas in patients with systemic lupus erythematosus on immunosuppressive therapy. N Engl J Med. 1973;289:842–3.CrossRefPubMedGoogle Scholar
  3. 3.
    Kuniyuki S, Shindow K. Multiple dermatofibromas accompanied by eruptive benign keratoses in a patient with systemic lupus erythematosus. J Dermatol. 1996;23:619–22.PubMedGoogle Scholar
  4. 4.
    Chohen PR. Multiple dermatofibromas in patients with autoimmune disorders receiving immunosuppressive therapy. Int J Dermatol. 1991;30:266–70.CrossRefGoogle Scholar
  5. 5.
    Tsunemi Y, Tada H, Saeki H, Ihn H, Tamaki K. Multiple dermatofibromas in a patient with systemic lupus erythematosus and Sjögren’s syndrome. Clin Exp Dermatol. 2004;29:483–5.CrossRefPubMedGoogle Scholar
  6. 6.
    Yamamoto T, Katayama I, Nishioka K. Mast cell numbers in multiple dermatofibromas. Dermatology. 1995;190:9–13.CrossRefPubMedGoogle Scholar
  7. 7.
    Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271–7.CrossRefPubMedGoogle Scholar
  8. 8.
    Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725.CrossRefPubMedGoogle Scholar
  9. 9.
    Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM, et al. Preliminary criteria for the classification of Sjögren’s syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum. 1993;36:340–7.CrossRefPubMedGoogle Scholar
  10. 10.
    Fujibayashi T, Sugai S, Miyasaka N, Hayashi Y, Tsubota K. Revised Japanese criteria for Sjogren’s syndrome (1999): availability and validity. Mod Rheumatol. 2004;14:425–34.CrossRefGoogle Scholar
  11. 11.
    Bombardier C, Gladman DD, Urowitz MB, Carton D, Chang CH. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum. 1992;35:630–40.CrossRefPubMedGoogle Scholar
  12. 12.
    Ackerman AB. Dermatofibroma. In: Ackerman AB, editor. Histologic. Diagnosis of inflammatory skin diseases. 2nd ed. Baltimore: Williams & Wilkins; 1997. p. 279–81.Google Scholar
  13. 13.
    Cerio R, Spaull J, Jones EW. Histiocytoma cutis: a tumour of dermal dendrocytes (dermal dendrocytoma). Br J Dermatol. 1989;120:197–206.CrossRefPubMedGoogle Scholar
  14. 14.
    Lin RY, Landsman L, Krey PR, Lambert WC. Multiple dermatofibromas and systemic lupus erythematosus. Cutis. 1986;37:45–7.PubMedGoogle Scholar
  15. 15.
    Bearcroft WGC, Amieson MF. An outbreak of subcutaneous tumors in rhesus monkey. Nature. 1958;182:195–6.CrossRefPubMedGoogle Scholar
  16. 16.
    Yamamoto T, Katayama I, Nishioka K. Involvement of basic fibroblast growth factor in fibroblast-stimulatory serum activity of a patient with systemic lupus erythematosus and multiple dermatofibromas. Dermatology. 1995;191:281–5.CrossRefPubMedGoogle Scholar

Copyright information

© Japan College of Rheumatology 2010

Authors and Affiliations

  1. 1.Department of DermatologyGifu University Graduate School of MedicineGifuJapan

Personalised recommendations